| CASE REPORT |
|
| Year : 2004 | Volume
: 41
| Issue : 4 | Page : 178-180 |
Early occurrence of acute myeloid leukemia following adjuvant radiotherapy and higher cumulative dose of cyclophosphamide in carcinoma breast
A Srivastava1, M Murari2, NR Datta1
1 Department of Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
2 Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Correspondence Address:
N R Datta
Department of Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 15659873 
We report a case of cancer breast developing acute myeloid leukemia (AML) within a relatively short interval of two
and a half years of her primary treatment. This could be attributed to post operative radiotherapy and a higher
cumulative dose of cyclophosphamide (14.4 gm) which had to be given as a part of her combination chemotherapy
regimen, initially as adjuvant and then later as salvage chemotherapy. The successful salvage therapy for secondary
AML instituted in this case is also discussed.
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