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| CASE REPORT |
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| Year : 2007 | Volume
: 44
| Issue : 4 | Page : 155-156 |
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Penile metastasis from rectal carcinoma
KM Murhekar1, U Majhi1, V Mahajan2, B Satheesan2
1 Department of Pathology, Cancer Institute (WIA), Adyar, Chennai - 600 020, India
2 Department of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai - 600 020, India
Correspondence Address:
B Satheesan
Department of Surgical Oncology, Cancer Institute (WIA), Adyar, Chennai - 600 020
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0019-509X.39378
Penile metastases are infrequent and often originate from genitor-urinary organs including bladder and prostate. In the present communication, we report an unusual case of penile metastasis from rectal adenocarcinoma. Though uncommon, this presentation is not unknown. A review of literature of penile metastases in colorectal cancers is also summarized here.
Keywords: Penile metastasis, rectal carcinoma
How to cite this article:
Murhekar K M, Majhi U, Mahajan V, Satheesan B. Penile metastasis from rectal carcinoma. Indian J Cancer 2007;44:155-6 |
| » Introduction | |  |
Despite its rich vascularization and extensive circulatory communication between the neighboring organs, metastatic involvement of the penis is relatively infrequent. Most of the primary tumors that metastasize to penis originate from pelvic uro-genital organs [1],[2],[3] and rarely from rectum and recto-sigmoid. [3],[4],[5],[6],[7] Patients with penile metastasis usually have widespread metastatic disease. [8] We report here a case of adenocarcinoma of rectum with isolated penile metastasis.
| » Case Report | | |
A 78-year-old gentleman presented with tenesmus, bleeding per rectum and altered bowel habits of six months duration in 2004. Clinical evaluation revealed an ulcero-proliferative growth starting at 2 cm. from anal verge extending upwards for 6 cm. involving the three fourth the circumference of the rectum. Biopsy of the lesion revealed adenocarcinoma grade II-III with nuclear grade intermediate [Figure - 1]. Computed tomographic study of the abdomen, pelvis and x-ray chest showed no evidence of distant metastasis. The patient underwent abdomino-perineal resection in January 2004. Intra-operatively there was no detectable metastasis in liver, peritoneum, para-aortic region and other intra-abdominal organs.
Postoperative histopathology revealed pathological T3 tumor [TNM Staging system 2002] with metastases in two regional lymph nodes [two out of nine nodes]. Though adjuvant chemo-radiotherapy was advised, patient failed to receive the same due to logistic reasons. He was on regular follow-up. In January 2006 he presented with phimosis and associated urinary difficulty. Clinical examination showed an indurated lesion palpable in the glans penis beneath the covered preputial skin with multiple hard nodules along the penile urethra and right corpus cavernosa close to the root of penis. Biopsy of the glans lesion was done after dorsal slit. It revealed metastatic adenocarcinoma [Figure - 2]. The slides of the primary tumor were compared with the penile lesion and the appearance was similar. Immunohistochemical study demonstrated positive staining of the tumor cells for carcino-embryonic antigen [CEA]. The patient was advised palliative chemotherapy, which he refused. He was subsequently catheterized after a month for urinary obstruction. He developed mild pain in the penile shaft after two months. He is on symptomatic and supportive care.
| » Discussion | | |
The first report of rectal carcinoma metastasizing to penis was described in 1870. [8] Since then few reports of metastatic penile carcinoma from primary tumor in rectum have been described in literature. [3],[4],[5],[6],[7] The most commonly accepted modes of spread to penis are through (1) retrograde venous spread (2) retrograde lymphatic spread (3) arterial spread (4) direct extension and (5) secondary embolization. Patients with penile metastasis usually have widespread metastatic disease and thereby poor general health. However, there are reports of delayed penile metastasis years after the primary has been treated and without evidence of any other metastatic lesions, as in the present case. The common presentations of penile metastasis are corporal mass, cutaneous nodule, malignant priapism or nonspecific refractory lower urinary tract symptoms. [9] Diagnosis is usually made by biopsy or corporeal aspiration. Management of penile metastasis is mainly palliative. The management is influenced by size of primary, extent of metastatic spread, general condition of the patient and also prognostic features of the primary tumor. The treatment modalities include radiotherapy, chemotherapy and surgery, with survival ranging from three to 18 months from time of diagnosis. Penectomy is a radical procedure advocated by some authors, [10] although the survival benefit remains controversial. Others have suggested that it should only be reserved for cases where metastases are isolated to only the penis. [11] Prognosis is usually poor and majority of patients presenting this way die within one year.
In conclusion, this report is an additional new case of primary rectal adenocarcinoma with isolated penile metastasis. Though penile metastatic lesions are infrequent, it should always be considered in the differential diagnosis in a patient with primary malignancies of urogenital organs and colorectum who is presenting with either synchronous or metachronus penile lesions.
| » References | | |
| 1. | Perez LM, Shumway RA, Carson CC, Fisher SR, Hudson WR. Penile metastasis secondary to supraglottic squamous cell carcinoma: Review of the literature. J Urol 1992;147:157-60.  |
| 2. | Powell BL, Craig JB, Muss HB. Secondary malignancies of the penis and epididymis: A case report and review of the literature. J Clin Oncol 1985;3:110-6. [PUBMED] [FULLTEXT] |
| 3. | Paquinj AJ, Roland SI. Secondary carcinoma of the penis: A review of literature and a report of nine new cases. Cancer 1956;9:626-32. |
| 4. | Tan BK, Nyam DC, Ho YH. Carcinoma of the rectum with a single penile metastasis. Singapore Med J 2002;43:39-40. [PUBMED] |
| 5. | Harper M, Arya M, Shah PJ. A lump in the penis. J R Soc Med 2002;95:38-9. [PUBMED] [FULLTEXT] |
| 6. | Banerjee GK, Lim KP, Cohen NP. Penile metastasis: An unusual presentation of metastatic colonic cancer. J R Coll Surg Edinb 2002;47:763-4. [PUBMED] |
| 7. | Lo S, Crew J. Penile metastasis from rectal carcinoma. Singapore Med J 2004;45:299. [PUBMED] [FULLTEXT] |
| 8. | Abeshouse BS, Abeshouse GA. Metastatic tumours of the penis: A review of the literature and a report of two cases. J Urol 1961;86:99-112. [PUBMED] |
| 9. | Trulock TS, Wheatley JK, Walton KN. Secondary tumors of penis. Urology 1981;17:563-5. [PUBMED] |
| 10. | Mukamel E, Farrer J, Smith RB, deKernion JB. Metastatic carcinoma to penis: when is total penectomy indicated? Urology 1987;29:15-8. [PUBMED] |
| 11. | Haddad FS. Penile metastases. Urology 1987;29:464. [PUBMED] |
[Figure - 1], [Figure - 2]
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