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Year : 2010  |  Volume : 47  |  Issue : 2  |  Page : 139-141

Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer

Wiwanitkit House, Bangkhae, Bangkok, 10160, Thailand

Correspondence Address:
V Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok, 10160
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.63003

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Background : Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention. Materials and Methods : In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool. Results : According to this study, 10 strong possible ligands were identified. Conclusion : These sites can be useful for further drug development studies.


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