Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :964
Small font sizeDefault font sizeIncrease font size
Navigate here
  Next article
  Previous article 
  Table of Contents
Resource links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (231 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded389    
    Comments [Add]    
    Cited by others 3    

Recommend this journal


Year : 2010  |  Volume : 47  |  Issue : 2  |  Page : 98-99

From pure research imaging tool to PET-guided personalized medicine in oncology: A true revolution in modern medicine

Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Mumbai, India

Date of Web Publication5-May-2010

Correspondence Address:
S Basu
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Mumbai
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.62994

Rights and Permissions

How to cite this article:
Basu S. From pure research imaging tool to PET-guided personalized medicine in oncology: A true revolution in modern medicine. Indian J Cancer 2010;47:98-9

How to cite this URL:
Basu S. From pure research imaging tool to PET-guided personalized medicine in oncology: A true revolution in modern medicine. Indian J Cancer [serial online] 2010 [cited 2022 Nov 26];47:98-9. Available from:

The impact of molecular imaging with PET(Positron Emission Tomography) and PET-CT (PET-Computed Tomography) in the practice of oncology has been truly revolutionary. This powerful imaging technology has become the cornerstone in the management of a wide array of malignancies, where it has become essential in disease staging, monitoring response to treatment, planning and choosing appropriate therapies, detecting recurrence, characterizing tumor biology and thereby predicting prognosis. [1],[2] The detailed structural and functional imaging information provided by PET-CT has significantly improved lesion delineation and characterization both at the primary and the metastatic sites and is now regarded by many as the 'one-stop-shop' for several malignancies. In this treatise, the authors have made an attempt to have a critical look at the impact of PET and PET-CT imaging in the practice of oncology from all the aforementioned aspects. This is a topic which many of us are passionate about and it is sincerely hoped that these scholarly reviews written by a stellar group of authors, which the editor is delighted to present to the readers, will provide comprehensive and useful sources of reference in the next few years.

The fluorodeoxyglucose (FDG) technique was introduced in 1976 by the investigators at the University of Pennsylvania, and was initially proposed as a novel tracer to determine regional brain function in normal physiologic states and in neuropsychiatric disorders. Subsequently, the critical role of PET imaging with FDG and with other novel tracers as molecular probes has been demonstrated in the investigation of a number of malignancies. One of the highlights of this minisymposium is to have Professor Abass Alavi of the Hospital of University of Pennsylvania as a co-author to two reviews. He is an internationally renowned expert in the modern imaging sciences, especially in the clinical applications of PET imaging for the detection of cancer as well as neurological, cardiovascular, and infectious disorders. Dr Alavi was very instrumental in introducing FDG into the practice of medicine. In fact, he was the first scientist to administer FDG to two normal human volunteers in August, 1976, at the University of Pennsylvania. Brain and whole body images were obtained with an ordinary (non-PET) nuclear scanner which demonstrated the concentration of FDG in the brain and other organ of body.

We are now in the era of evidence-based medicine where it is important to have a critical look at the impact of FDG-PET and PET-CT on each of the malignancies, based upon the published literature. The first review by Kumar and colleagues [3] has been dedicated to this end. As the new literature on PET-CT imaging is emerging, such academic exercise, from time to time, is pivotal to enhance the knowledge of the practicing oncologists and to define the precise role of this modality in each setting.

While the clinical PET imaging over the last two decades has been dominated by FDG across the world, new PET tracers are on the horizon that can provide information on various aspects of metabolism in a variety of tumors and it is likely that the trend in the practice of PET will undergo significant changes in the next several years because of the anticipated increase in use of these novel PET agents. Dr Caroli and colleagues [4] from the University of Bologna, Italy, have been one of the most active groups in this area and have built up their review on this very important topic that has been relatively less explored at this point but is evolving rapidly in the recent years. As the authors mention, FDG-PET shows significant shortcoming in certain malignancies like prostate cancer, liver cancer, central nervous system (CNS) tumors and neuroendocrine tumors (NET). The introduction of Gallium-68 labeled radiopharmaceuticals as viable PET agents has added a new dimension to the management of patients with NET by providing high quality images compared with planar or Single photon emission computed tomography (SPECT) with single photon emitting preparations. The development of 68 Ga-DOTA labeled somatostatin analogues has been the key to this success and this has further stimulated research into the development of DOTA-derivative peptides and led to the evolution of generator-based 68 Ga-PET radio pharmacy. 18 F-labeled DOPA has demonstrated similar promise in this group of tumors. Similarly, Choline labeled with either 11 C or 18 F, which has a high affinity for malignant prostate tissue, has been a significant advance in prostate cancer imaging. The current experience with such agents is relatively limited and therefore prospective studies are required to further define their precise role in different tumors.

The practice of Nuclear Medicine as well as Clinical Oncology in the pediatric population has been dealt with on a different note, especially over the last two decades, in order to address the diseases and issues that are specific to this age group. Similar concerns, though exist in the day-to-day practice of PET-CT imaging, are relatively unexplored. In Part 2 of this mini symposium, the readers will have an opportunity to read about a holistic approach towards the application of FDG-PET and PET-CT in pediatric oncology with the help of Dr Samuel who has elegantly portrayed important aspects. Though there may been some overlapping topics between her article and the first review by Kumar et al. they will provide the reader with a broader perspective.

Utilizing the invaluable functional information of PET for radiotherapy planning has greatly interested the radiation oncologists and the nuclear medicine fraternity alike. The introduction of hybrid imaging with PET-CT has provided significant impetus and revolutionized to PET based RT planning. Gupta and Beriwal, [5] in their scholarly review, overview the current status and advantages of radiation treatment planning based on tumor biology rather than solely upon tumor morphology. The future potential of the combined structure-function approach in this area is limitless and a fruitful collaboration between the radiation oncologists and the nuclear medicine physician is crucial for the success of this promising application.

Individualizing treatment in cancer patients is an evolving concept at present, which many of us believe will rely heavily on the success of metabolic imaging with current and the future novel PET tracers and prove to be significantly superior to the existing structural imaging techniques. It is perceivable that in the near future, the introduction of a large number of organ-specific and disease-specific PET tracers coupled with development of sophisticated techniques like incorporation of MRI into hybrid devices will substantially enhance the role of combined structure-function approach in the management of cancer and other serious disorders.

The introduction of PET and subsequently the development of hybrid imaging has been probably the single most innovation in recent times in the field of oncological imaging. Hence, it was a privilege for the editor to put together a mini-symposium on this very important topic for the Indian Journal of Cancer. This provided the authors and indeed, the guest editor, with the opportunity to address, in considerable depth, the many facets of the PET imaging in the practice of oncology. I hope that the readers will find these remarkable reviews highly informative as much as I have.

  References Top

1.Alavi A, Reivich M. Guest editorial: The conception of FDG-PET imaging. Semin Nucl Med 2002;32:2-5.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Basu S, Alavi A. Unparalleled contribution of 18F-FDG PET to medicine over 3 decades. J Nucl Med 2008;49:17N-21N, 37N.  Back to cited text no. 2      
3.Kumar R, Dhanpati H, Malhotra A. Clinical applications of positron emission tomography-computed tomography in oncology. Indian J Cancer 2010;47:100-19.  Back to cited text no. 3  [PUBMED]  Medknow Journal  
4.Caroli P, Nanni C, Rubello D, Alavi A, Fanti S. Non-FDG PET in the practice of oncology. Indian J Cancer 2010;47:120-5.  Back to cited text no. 4  [PUBMED]  Medknow Journal  
5.Gupta T, Beriwal S. PET/CT-guided Radiation Therapy Planning: From Present to the Future. Indian J Cancer 2010;47:126-33.  Back to cited text no. 5  [PUBMED]  Medknow Journal  

This article has been cited by
1 Potential Clinical Utility of FDG-PET in Non-malignant Pulmonary Disorders: A Pilot Study
Jyotsna M Joshi, Vinaya S. Karkhanis, Sandip Basu, Makaresh Yadav
The Indian Journal of Chest Diseases and Allied Sciences. 2022; 58(3): 165
[Pubmed] | [DOI]
2 Correlating and Combining Genomic and Proteomic Assessment with In Vivo Molecular Functional Imaging: Will This Be the Future Roadmap for Personalized Cancer Management?
Bhakti Basu,Sandip Basu
Cancer Biotherapy and Radiopharmaceuticals. 2016; 31(3): 75
[Pubmed] | [DOI]
3 result 1 Document The scope and potentials of functional radionuclide imaging towards advancing personalized medicine in oncology: Emphasis on PET-CT
Authors of Document Basu, S.
Source of the Document Discovery Medicine. 2013;


Print this article  Email this article
Previous article Next article


  Site Map | What's new | Copyright and Disclaimer | Privacy Notice
  Online since 1st April '07
  2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow