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Year : 2011  |  Volume : 48  |  Issue : 1  |  Page : 94-98

Helicobacter pylori infection in relation to gastric cancer progression

1 Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad - 500 016, India
2 Sai Nikith Speciality Hospital and Laparoscopic Center, Kothapet, Hyderabad - 500 036, India
3 Department of Gastroenterology, Gandhi Hospital, Secunderabad - 500 003, India

Correspondence Address:
A Venkateshwari
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad - 500 016
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.75840

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Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.


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