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  Table of Contents  
Year : 2011  |  Volume : 48  |  Issue : 2  |  Page : 262-264

Implant retained prosthetic rehabilitation in the case of histiocytosis X of the mandible

1 Department of Dental and Prosthetic Surgery, Tata Memorial Hospital, Dr. E. Borges Road Parel, Mumbai, India
2 Department of Oral Maxillofacial Surgery, D. Y. Patil Dental College, Mumbai, India

Date of Web Publication11-Jul-2011

Correspondence Address:
K P Dholam
Department of Dental and Prosthetic Surgery, Tata Memorial Hospital, Dr. E. Borges Road Parel, Mumbai
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.82888

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How to cite this article:
Dholam K P, Pusalkar H A, Kapadia K H. Implant retained prosthetic rehabilitation in the case of histiocytosis X of the mandible. Indian J Cancer 2011;48:262-4

How to cite this URL:
Dholam K P, Pusalkar H A, Kapadia K H. Implant retained prosthetic rehabilitation in the case of histiocytosis X of the mandible. Indian J Cancer [serial online] 2011 [cited 2021 Dec 1];48:262-4. Available from: https://www.indianjcancer.com/text.asp?2011/48/2/262/82888


Histiocytosis X, a name suggested by Sichenateen (for Langerhans cell histiocytosis) in 1953, is a disorder of the reticuloendothelial system. [1] It is a disease of unknown etiology characterized by the proliferation of pathological Langerhans cells. It is a rare pediatric disease of unknown etiology affecting one to five children per one million each year, adult cases have also been reported. [2] The head and neck region is affected in 90% of the cases. [3]

The incidence of oral manifestations of Langerhans cell histiocytosis (LCH) with oral lesions has been reported to be as high as 77%. The prognosis of a patient with the localized form of this disease is excellent. This is a case presentation of Histiocytosis X of the mandible and its dental rehabilitation.

A 12-year-old male reported with a history of a diffuse, nontender, hard swelling on the left mandibular and submandibular region since a year. Level III nodes were palpable (2 x 2 cm 2 ). An Orthopantomograph (OPG) showed multiple osteolytic lesions [Figure 1]. A skeletal survey revealed a lytic lesion in the frontoparietal region with osteopenia in the calvarial bones. Focal scalloping of the outer table of the skull vault in the left frontoparietal region was seen on a magnetic resonance imaging (MRI) scan. The bone scan presented with an increased concentration on the body and ramus of the left mandible. The rest of the skeleton was normal. The genetic anomaly factor was not seen in either the immediate or distant family members.
Figure 1: OPG showing a punched out osteolytic lesion in the left mandible

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Meticulous curettage of the mandibular granuloma was completed. The pathological fracture of the outer table of the mandible was noted.

The patient was given three cycles of chemotherapy (Etopsiode and methyl prednisolone) with concurrent local radiotherapy (2000 Gy). The skull lesion was considered as quiescent and not radiated. The patient showed good response to the treatment. The OPG showed a new bone formation and healing of the fractured border of the mandible. The lingually tilted mandibular left second molar was set in an upright position orthodontically. On the patient attaining 16 years of age, an implant-retained fixed bridge was planned [Figure 2].
Figure 2: Preoperative intraoral view

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Three Cylindrical Implants [(3.5 x 8 mm) x 1, (3.5 x 10 mm) from Hi-tec implants Ltd., Galgalei Plada, St. Industrial zone, Herzlia, Israel PO box 2022, Herzalia 46722] were placed [Figure 3]. [4] After a six-month healing period, the implants were exposed and healing caps were attached [Figure 4]. The prosthetic phase was completed after one month. Impression posts and implant analogs were attached on the implant [Figure 5]. Additional silicone impressions were made and the die stone models were prepared for fabricating the wax pattern, for metal casting. A metal trial was done [Figure 6]. Jaw relations and a face-bow transfer were recorded and the models were mounted for fabrication of the ceramic superstructure. The finished metal-ceramic restoration was tried in the patient's mouth to check the fit. Occlusal adjustments were conducted to achieve a stable occlusion. The metal ceramic restoration was cemented [Figure 7] and oral hygiene instructions were given to the patient, with follow-up every six months.
Figure 3: Surgical insertion of implants in the edentulous site

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Figure 4: Postoperative OPG showing healed lesion of the mandible with the titanium fixtures

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Figure 5: Impression posts attached to the implants

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Figure 6: Metal trial of the fixed partial denture

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Figure 7: Implant retained fixed partial denture in place

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Osseointegrated implants play a major role in functional oral rehabilitation. [5] The goal of treating any disease is to control and cure the disease process and rehabilitate the patients, so they can continue their normal functions as far as possible, thus contributing to their quality of life.

 » References Top

1.Rapp GE, Motta AC. Periodontal disease associated with Langerhans cell histiocytosis. A Case report. Braz Dent J 2000;11:59-66.  Back to cited text no. 1
2.Cochrane LA, Prince M, Clarke K. Langerhans' cell histiocytosis in the paediatric population: Presentation and treatment of head and neck manifestations. J Otolaryngol 2003;32:33-7.  Back to cited text no. 2
3.García de Marcos JA, Dean Ferrer A, Alamillos Granados F, Ruiz Masera JJ, Barrios Sánchez G, Romero Ortiz AI, et al. Langerhans cell histiocytosis in the maxillofacial area in adults report of three cases. Med Oral Patol Cir Bucal 2007;12:E145-50.   Back to cited text no. 3
4.Leckhom U. Clinical procedures for treatment with Osseo integrated dental implants. J Prosthet Dent 1983;50:116-20.  Back to cited text no. 4
5.Adell RU, Rockler B, Branemark PI. A 15-year study of Osseo integrated implants in the treatment of edentulous jaw. Int J Oral surgery 1981;10:387-416.  Back to cited text no. 5


  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7]

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