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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 51  |  Issue : 1  |  Page : 35-39

Gastrointestinal stromal tumor: Analysis of outcome and correlation with c-kit status in Indian population


1 Medical and Pediatric Oncologist, Caritas Cancer Institute, Kottayam, Kerala, India
2 Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, India

Correspondence Address:
S Cyriac
Medical and Pediatric Oncologist, Caritas Cancer Institute, Kottayam, Kerala
India
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Source of Support: Technical support from Oncquest Laboratories Ltd., Conflict of Interest: None


DOI: 10.4103/0019-509X.134616

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Aims: The aim of the present study is to analyse the outcome and genotypic pattern of metastatic GIST patients which is largely unknown in India. Materials and Methods: The present study was a retrospective analysis of 24 patients of metastatic GIST. The case records were analysed for clinical profile, treatment response and prognostic factors. The archival samples were retrieved for c-kit mutation analysis in all but 5 patients for mutation analysis. Results: The median age of the study population was 56 years. At a median follow up of 29 months, the PFS was 45% at 2 years. Activating c-kit mutations were detected in 10 cases (52.6%). 80% of the mutations were located in Exon 11. Conclusions: The outcome of metastatic GIST patients has definitely improved from a virtually incurable state to a disease where median OS has reached 60 months. The genotype of Indian patients with GIST may be different from the western population which needs to be confirmed in a larger study.






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