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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 51  |  Issue : 6  |  Page : 9-12

Computed tomography-guided iodine-125 interstitial implantation as an alternative treatment option for lung cancer


1 Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China
2 Department of Interventional Radiology, Affiliated Hospital of Qingdao University, Qingdao, China
3 Department of Radiotherapy, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China
4 Department of Oncology and Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao, China

Correspondence Address:
W Xu
Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao
China
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Source of Support: This study is supported by Shandong Tackle Key Problems in Science and Technology (2010GSF10245), Conflict of Interest: None


DOI: 10.4103/0019-509X.151999

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Purpose: The aim was to evaluate the safety, feasibility and efficacy of computed tomography (CT)-guided percutaneous interstitial brachytherapy using radioactive iodine-125 ( 125 I) seeds for the treatment of lung cancer. Materials and Methods: Included in this study were 45 male and 35 female patients aged 52-85 years (mean 72-year) who were diagnosed with lung cancer. Of the 80 cases of lung cancer, 38 were pathologically confirmed as squamous cell carcinoma, 29 as adenocarcinoma, 2 as small cell lung cancer, and 11 as metastatic lung cancer. Percutaneous interstitial implantation of radioactive 125 I seeds was performed under CT guidance. The treatment planning system was used to reconstruct three-dimensional images of the tumor to determine the quantity and distribution of 125 I seeds to be implanted. Under CT guidance, 125 I seeds were embedded into the tumor, with the matched peripheral dose set at 100-130 Gy. Follow-up CT scan was done in 2-month to explore the treatment efficacy. Results: The procedure was successful in all patients. No major procedure-associated death occurred. The duration of follow-up was 6-month. Complete response (CR) was seen in 38 cases (47.5%), partial response (PR) in 27 cases (33.75%), stable disease (SD) in 10 cases (12.5%), and progressive disease in 5 cases (6.25%), with a local control rate (CR + PR + SD) of 93.75%. The 2-, 4- and 6-month overall response rate (CR + PR) was 78%, 83% and 81%, respectively. Conclusion: Implantation of CT-guided 125 I seeds is a safe and effective alternative option for the treatment of lung cancer.






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