Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :1945
Small font sizeDefault font sizeIncrease font size
Navigate here
Resource links
 »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »  Article in PDF (211 KB)
 »  Citation Manager
 »  Access Statistics
 »  Reader Comments
 »  Email Alert *
 »  Add to My List *
* Registration required (free)  

  In this article
 »  Abstract
 » Introduction
 »  Materials and Me...
 » Results
 » Discussion
 » Conclusion
 »  References
 »  Article Tables

 Article Access Statistics
    PDF Downloaded200    
    Comments [Add]    
    Cited by others 2    

Recommend this journal


  Table of Contents  
Year : 2015  |  Volume : 52  |  Issue : 1  |  Page : 57-59

Clinicopathological characteristics of ameloblastomas in Western Uttar Pradesh population: An institutional study

1 Department of Oral and Maxillofacial Pathology, Subharti Dental College, Meerut, Uttar Pradesh, India
2 Department of Oral and Maxillofacial Pathology, ESI Dental College, New Delhi, India
3 Department of General Surgery, Subharti Medical College, Meerut, Uttar Pradesh, India

Date of Web Publication3-Feb-2016

Correspondence Address:
S Gupta
Department of Oral and Maxillofacial Pathology, Subharti Dental College, Meerut, Uttar Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.175557

Rights and Permissions

 » Abstract 

Objective: The aim of this study was to compare the clinical, radiologic, and histopathological features of 28 intraosseous ameloblastomas. In addition, we compared the data obtained in this study with that of previous studies. Materials And Methods: Data with regard to age, gender, clinical manifestation, radiographic aspect, anatomical distribution, and histopathological subtypes were analyzed in 28 subjects. Results: The patients' age ranged from 7 years to 65 years (mean, 30.4 years). Sixteen (57.14%) of the 28 subjects were males, and 12 (42.85%) were females. A total of 22 cases (78.5%) were located in the mandible, posterior region was more often affected with 17 cases (77.27%) than only 5 cases (22.72%) in the anterior segment. Swelling was the most common symptom and was experienced by 12 (42.85%) patients. Radiographically, 14 cases (50%) were multilocular with a well-demarcated border. Of the remaining 14 cases, 10 were unilocular and 4 were unknown in appearance. The most common histopathological pattern was follicular followed by plexiform or acanthomatous. Conclusions: The clinical epidemiological profile to patients in the present study is similar to that in other populations, with follicular ameloblastoma being the most common histological subtypes seen.

Keywords: Ameloblastoma, clinicopathological, epidemiological, odontogenic tumor

How to cite this article:
Gupta S, Sexana S, Bhagwat S, Aggarwal P, Gupta P K. Clinicopathological characteristics of ameloblastomas in Western Uttar Pradesh population: An institutional study. Indian J Cancer 2015;52:57-9

How to cite this URL:
Gupta S, Sexana S, Bhagwat S, Aggarwal P, Gupta P K. Clinicopathological characteristics of ameloblastomas in Western Uttar Pradesh population: An institutional study. Indian J Cancer [serial online] 2015 [cited 2022 May 17];52:57-9. Available from:

 » Introduction Top

Odontogenic tumors are lesions derived either from epithelial or ectomesenchymal components of developing teeth or associated structures. These tumors represent only 1% of all jaw tumors.[1] Among odontogenic tumors, ameloblastomas and odontomas are the more prevalent pathological patterns. Ameloblastoma is a benign epithelial tumor with no ectomesenchymal neoplastic component. It has aspects of aggressiveness and local invasion, but is also asymptomatic and slow growing.[1] Both sexes are equally affected. The tumor is relatively uncommon and accounts for approximately 1% of all oral tumors.[2] Although rare in childhood, all age groups are affected. It is most common in the third and fourth decades. The tumor occurs predominantly in the mandible with figures as high as 99.1% being reported. A few cases of malignant change with distant metastasis have been reported in the literature.[2]

Radiographically, ameloblastomas present as multilocular and unilocular radiolucent lesions surrounded by a radiopaque border, located primarily in the posterior mandibular segment.[1] There are three clinical types of ameloblastoma: the solid or multicystic type, the unicystic type and the rare peripheral type.[2]

In relation to cellular pattern and organization, ameloblastoma can be classified into subtypes such as follicular, plexiform, acanthomatous, and granular. These subtypes can occur in isolation or combination.[1]

Some regional variations are reported in respect to age of occurrence, site, and biological behavior of these tumors.


This study was carried out to establish the relative incidence and provide clinic-pathologic information on the various histopathological types of ameloblastomas seen in the Oral Pathology Department of Subharti Dental College, Meerut. In addition, we compare the data obtained in this study with that of previous studies.

 » Materials and Methods Top

We retrieved 268 samples of oral tumors from the files of Oral Pathology Department of our college during the period 2004-2011 and out of those 47 samples were of odontogenic tumors with 28 cases of ameloblastomas. Data with regard to age, gender, clinical manifestation, radiographic aspect, anatomical distribution, and histopathological subtypes were analyzed. Regarding tumor location, maxillary cases were divided into anterior, premolar, and molar areas, whereas mandibular cases were divided into anterior, posterior, angle, and ramus.

 » Results Top

During a period of 8 years, a total of 268 biopsies of oral tumors were collected from our department archives. Of these 28 had confirmed diagnosis of ameloblastoma representing 10.44% of total cases.

Out of these 28 cases, 16 (57.14%) were males and 12 (42.85%) were females, making a male/female ratio of 1.3:1. Young adults in their second, third and fourth decades of life were most affected by the tumors. The patient age varied from 7 years to 65 years, with an average of 30 years of age at the time of diagnosis and the data is provided in [Table 1].
Table 1: Age distribution of ameloblastoma

Click here to view

The anatomical sites of all the tumors are presented in [Table 2]. In general, mandible was the most common site corresponding to 22 cases (78.5%) of ameloblastomas. Of these cases, the posterior region was affected more often (n = 17; 77.27%) than the anterior segment (n = 5; 22.72%). The maxilla was less affected (n = 6) as compared to mandible, with the mandible to maxilla ratio being 3.6:1.
Table 2: Site distribution and type of ameloblastoma

Click here to view

The main clinical feature of tumors was a swelling of the affected region (n = 12; 42.85%). This was significant in relation to less frequent signs and symptoms such as pain (n = 4; 14.28%), pain and paresthesia (n = 2; 7.14%), dental mobility (n = 1; 3.57%), swelling and purulent discharge (n = 3; 10.71%), pain and swelling (n = 5; 17.85%) and pain and discomfort (n = 1; 3.57%) [Table 3].
Table 3: Chief complaint and symptoms

Click here to view

Follicular ameloblastoma was the most common histopathological subtype seen (7). Data related to patient's histopathological types and radiographic types are presented in [Table 4].
Table 4: Relationship between radiographic and histologic findings

Click here to view

[Table 2] presents the relation of this tumor type with the site of distribution of ameloblastoma. The follicular sub-type showed greater predilection for mandible with 11 lesions diagnosed in this site (39.28%) whereas only 6 cases (21.42%) were observed in the maxilla.

In some cases (n = 4; 14.28%), the radiographic aspects were not recorded in the clinical records. In 14 cases (50%), a multilocular radiolucent appearance was observed and in 10 cases (35.7%) a unilocular radiolucent appearance was observed as given in [Table 4].

The majority of the tumors (n = 20; 71.42%) were treated with a radical form of surgery, including ample bone resection with a safety margin of healthy bone of about 1 cm. Only 2 (7.14%) young patients (<21 years) with unicystic ameloblastomas were treated conservatively with enucleation or curettage and for the rest 6 cases, the treatment record was not available.

 » Discussion Top

Several reports of ameloblastoma have been published.[1],[3],[4],[5],[6],[7] Ameloblastoma is a tumor that has a worldwide distribution.[8] Ameloblastoma occurs with slight male predominance than females

[4] as was also noted in the present study, but sometimes female predominance is also seen, reported in another American population.[9]

The age distribution is usually from the first to the seventh decade of life with the mean age in the fourth decade, two-thirds of the patients being younger than 40 years.[2] In the present study, the age ranged from 7 years to 65 years, with a distinct peak in the third decade, a feature also noted in another Indian study[10] and Zimbabwean study.[2] It also showed peak incidence in the fourth decade as seen in Chinese and Brazil population along with second and third decade.[6]

Approximately 80% of tumors are found in the mandible.[1],[2],[3],[5],[6],[11],[12] The maxilla is infrequently affected. In the present study, 78.5% of the ameloblastomas were found in the mandible, a figure similar to another Indian study.[10] The molar and premolar area is more frequently involved site as seen in the present study with similar findings seen in Chinese[6], Zimbabwean[1] and American population.[9]

In black children, ameloblastomas occur more frequently in the anterior region whereas in black adults, posterior region is more affected.[13] According to Kim and Jang,[3] the frequency of ameloblastoms in young patients (<19 years) is relatively low, occurring in only 10-15% of all reported cases. However, our results show a greater frequency, around 28.6% for this group of individuals. This finding is similar to those observed by Clades Pereira et al.[1] amounting to 25% for under 19 years age group. However, in our study the frequency of patient below 40 years age group was around 82% compared to only 78% of the patients in the study conducted by Chidzonga et al.[2] for similar age group.

Our observation revealed, follicular ameloblastoma is the most prevalent histopathological variant (39%) in the present study, which is in agreement with reports in the literature[3],[7] and is followed by acanthomatous 14.28% and unicystic 14.25% and plexiform 10.71% type.

Among all clinical features, swelling accounted for 42.85% of the symptoms and was the most common complaint of the patients in this study. Korean population showed almost similar clinical finding (38%).[3]

The radiographic appearance in this study was predominantly multilocular (50%), whereas unilocular, radiolucency was noted in 35.7% of the total cases.[2]

[Table 5] presents a comparative analysis of this study with other works published in the English literature since 2004. The relative frequencies of ameloblastomas, histopathological and clinical data are compared.

Table 5: Comparative analysis of the present study during the current decade

Click here to view

 » Conclusion Top

In conclusion, the present the study provides a baseline data on variants of ameloblastoma as obtained in a Western Utter Pradesh population.

The clinical epidemiologic profile of patients from the present study is very similar to other populations with regard to gender, age, and tumor location, with follicular ameloblastoma being the most common subtype in our population.[14]

 » References Top

Pereira F, De Araujo Melo E, Silva Gurgel CA, Cangussu MC, De Azevedo RA, Dos Santos JN. Clinicopathological and demographic characteristics of ameloblastomas in population of Bahia, Brazil. Rev Odonto Cienc 2010;25:250-5.  Back to cited text no. 1
Chidzonga MM, Lopez Perez VM, Portilla Alvarez AL. Ameloblastoma: The Zimbabwean experience over 10 years. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:38-41.  Back to cited text no. 2
Kim SG, Jang HS. Ameloblastoma: A clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:649-53.  Back to cited text no. 3
Tamme T, Soots M, Kulla A, Karu K, Hanstein SM, Sokk A, et al. Odontogenic tumours, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia. J Craniomaxillofac Surg 2004;32:161-5.  Back to cited text no. 4
Fernandes AM, Duarte EC, Pimenta FJ, Souza LN, Santos VR, Mesquita RA, et al. Odontogenic tumors: A study of 340 cases in a Brazilian population. J Oral Pathol Med 2005;34:583-7.  Back to cited text no. 5
Luo HY, Li TJ. Odontogenic tumors: A study of 1309 cases in a Chinese population. Oral Oncol 2009;45:706-11.  Back to cited text no. 6
Adebiyi KE, Ugboko VI, Omoniyi-Esan GO, Ndukwe KC, Oginni FO. Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med 2006;2:42.  Back to cited text no. 7
Ajagbe HA, Daramola JO. Ameloblastoma: A survey of 199 cases in the University of College Hospital, Ibadan, Nigeria. J Natl Med Assoc 1987;79:324-7.  Back to cited text no. 8
Regezi JA, Kerr DA, Courtney RM. Odontogenic tumors: Analysis of 706 cases. J Oral Surg 1978;36:771-8.  Back to cited text no. 9
Varkhede A, Tupkari JV, Mandale MS, Sardar M. Odontogenic tumor: A review of 60 cases. J Clin Exp Dent 2010;2:e183-6.  Back to cited text no. 10
Odukoya O. Odontogenic tumors: Analysis of 289 Nigerian cases. J Oral Pathol Med 1995;24:454-7.  Back to cited text no. 11
Ladeinde AL, Ajayi OF, Ogunlewe MO, Adeyemo WL, Arotiba GT, Bamgbose BO, et al. Odontogenic tumors: A review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:191-5.  Back to cited text no. 12
Ajagbe HA, Daramola JO. Primary tumors of the jaw in Nigerian children. J Natl Med Assoc 1982;74:157-61.  Back to cited text no. 13
Sriram G, Shetty RP. Odontogenic tumors: A study of 250 cases in an Indian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:e14-e21.  Back to cited text no. 14


  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]

This article has been cited by
1 Global incidence and profile of ameloblastoma: A systematic review and meta-analysis
Faqi Nurdiansyah Hendra,Ellen M. Van Cann,Marco N. Helder,Muhammad Ruslin,Jan G. de Visscher,Tymour Forouzanfar,Henrica C. W. de Vet
Oral Diseases. 2019;
[Pubmed] | [DOI]
2 Rate of Relapse After Enucleation of Solid/Multicystic Ameloblastoma Followed by Piezoelectric or Conventional Peripheral Ostectomy
Giuseppe Troiano,Alessandra Inghingolo,Rosario Serpico,Domenico Ciavarella,Lorenzo Lo Muzio,Gabriele Cervino,Marco Cicciù,Luigi Laino
Journal of Craniofacial Surgery. 2018; : 1
[Pubmed] | [DOI]


Print this article  Email this article


  Site Map | What's new | Copyright and Disclaimer | Privacy Notice
  Online since 1st April '07
  © 2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow