Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :448
Small font sizeDefault font sizeIncrease font size
Navigate here
Resource links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (848 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   Article Figures

 Article Access Statistics
    PDF Downloaded159    
    Comments [Add]    

Recommend this journal


  Table of Contents  
Year : 2015  |  Volume : 52  |  Issue : 3  |  Page : 260-261

Primary chondrosarcoma in the young

1 Department of Pathology, SDUMC, Kolar, Karnataka, India
2 Department of Orthopedics, SDUMC, Kolar, Karnataka, India

Date of Web Publication18-Feb-2016

Correspondence Address:
B N Gayathri
Department of Pathology, SDUMC, Kolar, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.176753

Rights and Permissions

How to cite this article:
Gayathri B N, Suresh T N, Harendra Kumar M L, Arun H S. Primary chondrosarcoma in the young. Indian J Cancer 2015;52:260-1

How to cite this URL:
Gayathri B N, Suresh T N, Harendra Kumar M L, Arun H S. Primary chondrosarcoma in the young. Indian J Cancer [serial online] 2015 [cited 2021 Jun 13];52:260-1. Available from:


Chondrosarcoma (CS) is primarily a tumor of adulthood, presenting most often in patients who are in the third to seventh decade of life. Its occurrence in children is rare. Although several studies describe the clinicopathologic features and behavior of chondrosarcoma in general, only a few reports specifically discuss chondrosarcoma occurring in patients less than 20 years of age.[1] The most frequent sites of involvement in children are appendicular skeleton, humerus, pelvic bones followed in frequency by femur and tibia.[1],[2] We present a case of chondrosarcoma of tibia in an 18-year-old female.

Patient presented with painful swelling over proximal aspect of left leg since 2 years. There was sudden increase in size of the swelling since 6 months. No history of predisposing hereditary conditions to chondrosarcoma like Ollier's disease, Maffucci syndrome, multiple hereditary exostosis. No history of radiation or chemotherapy. On local examination, there was a diffuse, firm to hard swelling measuring 20 cm × 20 cm over proximal one-third of left leg extending to middle one-third. Alkaline phosphatase and acid phosphatase was elevated. Radiograph of left tibia showed large soft tissue mass containing speckled calcifications. CT scan showed lytic lesion arising from the tibia with disruption of the cortex and an extensive soft tissue mass containing calcification. Multiple aspirations yielded blood and blood elements with foci of myxoid areas, aspiration cytology was inconclusive. Left above knee amputation was done.

On gross examination, there was swelling in the upper end of the tibia measuring 18 × 17 cm. Cut section showed large exophytic grey-white tumor with foci of myxoid change measuring 16 × 15 cm, extending in to adjacent soft tissue, joint space, and lower end of femur [Figure 1]. Soft tissue resected margin appeared free from tumor. Microscopy showed lobules of neoplastic cartilage with hypercellularity, nuclear pleomorphism, few with intranuclear grooves, and prominent nucleoli. These lobules were separated by cellular spindle cell stroma showing moderate degree of pleomorphism [Figure 2]. Also, an extensive focus of calcification was noted. Histological diagnosis of chondrosarcoma grade 2 was made. The patient had an event-free post-operative course, and there was no evidence of local recurrence or metastasis.
Figure 1: Gross photograph showing large exophytic grey white tumor in tibia extending in to adjacent soft tissues

Click here to view
Figure 2: Microphotograph showing lobules of neoplastic cartilage separated by cellular spindle cell stroma (H and E, ×100)

Click here to view

In one study, it was seen that chondrosarcoma affecting young individuals is, in general, a more ominous tumor as compared with adults and is relatively more high-grade.[1] However, in another study, it was proved that tumors were low-grade, and prognosis in childhood chondrosarcoma is no different from that in adult chondrosarcoma.[2]

For low grade CS's, prognosis is excellent after an adequate excision, with very low rates of recurrence or spread.[3] In a review of 70 young patients with low-grade CS of the appendicular skeleton, only 3 presented with metastasis. Radiation therapy and chemotherapy should be reserved for recurrences or distant metastasis.[4]

  References Top

Huvos AG, Marcove RC. Chondrosarcoma in the young. A clinicopathologic analysis of 79 patients younger than 21 years of age. Am J Surg Pathol 1987;11:930-42.  Back to cited text no. 1
Young CL, Sim FH, Unni KK, McLeod RA. Chondrosarcoma of Bone in children. Cancer 1990;66:1641-8.  Back to cited text no. 2
Leerapun T, Hugate RR, Inwards CY, Scully SP, Sim FH. Surgical Management of Conventional grade I Chondrosarcoma of long bones. Clin Orthop Relat Res 2007;463:166-72.  Back to cited text no. 3
Aprin H, Riseborough EJ, Hall JE. Chondrosarcoma in children and adolescents. Clin Orthop Relat Res 1982;166:226-32.  Back to cited text no. 4


  [Figure 1], [Figure 2]


Print this article  Email this article


  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow