Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :116
Small font sizeDefault font sizeIncrease font size
Navigate here
Resource links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (1,375 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   Article Figures

 Article Access Statistics
    PDF Downloaded160    
    Comments [Add]    

Recommend this journal


  Table of Contents  
Year : 2015  |  Volume : 52  |  Issue : 3  |  Page : 447-448

Aggressive primary malignant myoepithelioma of the maxillary sinus

1 Head and Neck Surgeon, Department of Surgical Oncology, Fortis Cancer Institute, Mulund West Mumbai, India
2 Department of Internal Medicine, Florida Hospital Medical Center, Orlando, Florida, Water Lake, United States

Date of Web Publication18-Feb-2016

Correspondence Address:
A H Hakeem
Head and Neck Surgeon, Department of Surgical Oncology, Fortis Cancer Institute, Mulund West Mumbai
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.176739

Rights and Permissions

How to cite this article:
Hakeem A H, Hakeem I H. Aggressive primary malignant myoepithelioma of the maxillary sinus. Indian J Cancer 2015;52:447-8

How to cite this URL:
Hakeem A H, Hakeem I H. Aggressive primary malignant myoepithelioma of the maxillary sinus. Indian J Cancer [serial online] 2015 [cited 2021 May 9];52:447-8. Available from: https://www.indianjcancer.com/text.asp?2015/52/3/447/176739


Myoepitheliomas are benign and very rare tumors that constitute about 1% of the salivary gland tumors.[1] Only 10% of the myoepithelioma's are malignant.[1] Most common site of occurrence is parotid, with only few case reports from the maxillary sinus.[2],[3],[4] We report a case of 31-year-old female who presented to us with residual tumor in the region of left maxillary sinus. The lesion had been enucleated in the regional hospital one month ago with histopathological diagnosis of spindle cell tumor. On oral examination, she hadfleshy mass involving left upper alveolus. She had no palpable cervical lymphadenopathy. CT scan revealed residual mass lesion in the left maxillary alveolus along its lingual and buccal cortices. There was destruction of the anterior wall and posterior-lateral wall of the left maxillary antrum. Metastatic work up did not reveal any distant metastases. Total maxillectomy was performed. Histopathology established the diagnosis of a malignant myoepithelioma [Figure 1] and [Figure 2]. Immuno-histochemical reactions were positive for cytokeratins, vimentin, SMA, S-100 proteincalponin and negative for CD-10, which confirmed the diagnosis of malignant myoepithelioma.
Figure 1: Under low power showing sheets and cords of ovoid to spindle component with moderate amount of pale to eosinophilic cytoplasm

Click here to view
Figure 2: Under high power showing ovoid to spindle cells with uniform, mildly hyperchromatic nuclei, and inconspicuous nucleolei

Click here to view

Post-operative period was uneventful. She also received 60 Gy/33# of adjuvant radiotherapy. Eight months after completion of the radiotherapy, tumor recurred locally and she complained of pain in the right lower quadrant of abdomen. There was vague mass in the right lower abdomen, which was tender to palpation. CT abdomen revealed huge variegated partially necrotic adnexal mass extending to the right para-umbilical region with mass displacing the uterus to the left [Figure 3]. This mass was adherent to the small bowel. Enlarged left para-aortic nodes were also seen [Figure 4]. Patient refused any further diagnostic or therapeutic intervention.
Figure 3: CT scan abdomen showing huge varigated partially necrotic right adnexal mass extending to right para-umbilical region with mass displacing uterus to left and adherent to adjacent small bowel

Click here to view
Figure 4: CT scan abdomen showing left para-aortic lymphadenopathy

Click here to view

Malignant myoepitheliomas may arise denovo or develop from a pre-existing myoepithelioma or pleomorphic adenoma. Only few cases of the primary maxillary sinus malignant myoepitheliomas have been reported in the English language literature since Graadt van Roggen et al.[4] reported the first case in 1998.

Controversy exists as to degree of malignancy and metastasis of malignant myoepithelioma, but the rate of recurrence is high.[1],[2],[3],[4] In the present case, recurrence at the primary site andnecrotic lesions inthe adnexa, probably metastases was seen in only 8 months post-surgery, and radiotherapy reveals the aggressive biological nature of the malignant myoepitheliomas.

  References Top

Nagao T, Sugano I, Ishida Y, Tajima Y, Matsuzaki O, Konno A, et al. Salivary gland malignant myoepithelioma: A clinicopathologic and immunohistochemical study of ten cases. Cancer 1998;83:1292-9.  Back to cited text no. 1
Zhou SH, Ruan LX, Gong L, Wang SQ. Primary malignant myoepithelioma of the left maxillary sinus: A case report. J Int Med Res 2008;36:362-5.  Back to cited text no. 2
Hata M, Tokuuye K, Shioyama Y, Nomoto S, Inadome Y, Fukumitsu N, et al. Malignant myoepithelioma in the maxillary sinus: Case report and review of the literature. Anticancer Res 2009;29:497-501.  Back to cited text no. 3
Graadt van Roggen JF, Baatenberg-de Jong RJ, Verschuur HP, Balhuizen JC, Slootweg PJ, van Krieken JH. Myoepithelial carcinoma (malignant myoepithelioma):First report of an occurrence in the maxillary sinus. Histopathology 1998;32:239-41.  Back to cited text no. 4


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


Print this article  Email this article


  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow