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Year : 2016  |  Volume : 53  |  Issue : 1  |  Page : 74-76

Pap test accuracy and severity of squamous intraepithelial lesion

Department of Gynecology and Obstetrics, Universidade Potiguar–UnP, Natal, Brazil

Correspondence Address:
RNO Cobucci
Department of Gynecology and Obstetrics, Universidade Potiguar–UnP, Natal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0019-509X.180825

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Background: Cytology smears and guided biopsies are the most widely used diagnostic standards for cervical cancer (CC) screening in the developing countries. Aim: To evaluate the performance of conventional cytology in estimating the presence and grade of cervical disease against the reference standard of histopathology. Settings and Design: After primary screening for CC, directed biopsies were performed and compared with histopathology results. Materials and Methods: Papanicolaou (Pap) smears and biopsies from 3194 women in the age group of 14-98 years were included. Cytology results were provided by doctors who performed the cervical biopsies. Statistical Analysis: The accuracy of Pap smear was measured by sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) calculated using the statistical analysis program PSPP 0.7.8. Results: The sensitivity of conventional cytology (Pap smear) for women with low-grade cervical intraepithelial neoplasia or less serious lesions (CIN1-) was 93% and specificity was 73%. The sensitivity and specificity of cytology for women with high-grade cervical intraepithelial neoplasia or cancer (CIN2+) was 64% and 84%, respectively. Conclusion: Cytology is a sufficiently sensitive test for detection of cervical lesions and can be used as a primary testing tool to triage.


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