|LETTERS TO THE EDITOR
|Year : 2019 | Volume
| Issue : 2 | Page : 182
Gall bladder cancer in Delhi - some thoughts
Department of Cancer Registry and Epidemiology, Dr. B Borooah Cancer Institute, Guwahati, Assam; Cancer Research Foundation, India
|Date of Web Publication||2-May-2019|
Department of Cancer Registry and Epidemiology, Dr. B Borooah Cancer Institute, Guwahati, Assam; Cancer Research Foundation
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Krishnatreya M. Gall bladder cancer in Delhi - some thoughts. Indian J Cancer 2019;56:182
I read with interest the article by Malhotra et al. on the epidemiology of gall bladder cancer (GBC) in urban Delhi over a 25-year period. The authors must be commended for this excellent analysis.
The study has demonstrated a plateau in the incidences followed by a rise in GBC cases from 2005 onwards in both males and females, with an estimated average annual percentage change of 6.0% (95% confidence interval: 3.6–8.5). This assumes significance in the light of growing evidence that has implicated the role of heavy metals in the causation of GBC., Efforts should be made to look into the industrial policy or trends in the environmental pollution of the National Capital Region (NCR) of Delhi that took place in the 1990s, as it could have impacted the rising incidence of GBC. A white paper on water pollution of Delhi has shown the pollution load being discharged into River Yamuna, which is the main source of water for the NCR; there was a consistent rising biochemical oxygen demand from 1988 to 1996. Biochemical oxygen demand is a marker for water pollution and is the amount of dissolved oxygen required by aerobic biological organisms to break down organic material present in a given water sample at a certain temperature over a specific period of time. Similarly, the growth of small-scale industries in Delhi has more than doubled from 42,000 in 1981 to 85,050 in 1991. Reviewing environmental pollution and risk of cancer is assuming greater significance nowadays. Furthermore, recent research has shown an alarming contamination of groundwater and soil by heavy metals due to unauthorized e-waste recycling site in Delhi.
From the data of the present study, it would also have been of scientific interest to project the current and future burden of GBC cases assuming that the same trends continue.
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Conflicts of interest
There are no conflicts of interest.
| » References|| |
Malhotra RK, Manoharan N, Shukla NK, Rath GK. Gallbladder cancer incidence in Delhi urban: A 25-year trend analysis. Indian J Cancer 2017;54:673-7.
] [Full text]
Chhabra D, Oda K, Jagannath P, Utsunomiya H, Takekoshi S, Nimura Y, et al.
Chronic heavy metal exposure and gallbladder cancer risk in India, a comparative study with Japan. Asian Pac J Cancer Prev 2012;13:187-90.
Ai Z, Lu W, Qin X. Arsenic trioxide induces gallbladder carcinoma cell apoptosis via downregulation of bcl-2. Biochem Biophys Res Commun 2006;348:1075-81.
Panwar RM, Ahmed S. Assessment of contamination of soil and groundwater due to e-waste handling. Curr Sci 2018;114:166-73.
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