utd_medknow
Indian Journal of Cancer
Home  ICS  Feedback Subscribe Top cited articles Login 
Users Online :1369
Small font sizeDefault font sizeIncrease font size
Resource Links
     Search Pubmed for
 
    -  Sahasrabuddhe NA
    -  Korlimarla A
    -  Kulkarni M
    -  Kusuma V
    -  Prabhu JS
    -  Dixit S
    -  Deshmukh C
    -  Sridhar T S
    -  Phatak A
    -  Koppiker C
 

 Article Access Statistics
    Viewed208    
    PDF Downloaded3    

Recommend this journal

 

 CASE REPORT

NGS-based profiling of key cancer genes in Indian triple-negative breast cancer patients reinforces molecular heterogeneity of the disease


1 PierianDx India Pvt. Ltd. Pune, Maharashtra, India
2 St. John's Research Institute, Bengaluru, Karnataka, India
3 Prashanti Cancer Care Mission (PCCM); Center for Translational Cancer Research - a joint initiative of PCCM and Indian Institute of Science Education and Research (IISER), Pune, Maharashtra, India
4 Prashanti Cancer Care Mission (PCCM), Pune, Maharashtra, India

Correspondence Address:
Nandini A Sahasrabuddhe,
PierianDx India Pvt. Ltd. Pune, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijc.IJC_432_20

Triple-negative breast cancers (TNBC) are one of the most aggressive forms of breast cancers. With poor patient outcomes, it presents a great burden on the healthcare systems. There have been some efforts to explore the genomic changes that occur in TNBCs. However, there is not enough data on Indian TNBCs. We sought to understand the mutational landscape of key cancer-associated genes in Indian TNBC patients using TruSeq Cancer Amplicon Panel. We sequenced 51 TNBC patient samples and found great heterogeneity amongst samples with respect to the genomic variants. Several previously reported including alterations in PI3K-AKT pathway genes were also identified. Likewise, we identified several novel high-frequency variants, for example, GNAQ F341S (17%), the functional role of which remains unclear. Our study lays the foundation of larger efforts needed to understand the genomic landscape of Indian TNBCs which can aid in classification and better therapeutic management of patients.




  Site Map | What's new | Copyright and Disclaimer
  Online since 1st April '07
  2007 - Indian Journal of Cancer | Published by Wolters Kluwer - Medknow