Expression of mismatch repair proteins in urothelial carcinoma of the urinary bladder
Rasheeda Mohamedali1, Amit K Adhya1, Swarnendu Mandal2, Suvradeep Mitra1
1 Department of Pathology and Lab Medicine, AIIMS, Bhubaneswar, Odisha, India
2 Department of Urology, AIIMS, Bhubaneswar, Odisha, India
Background: Urothelial carcinoma of the urinary bladder (UCUB) is a frequently diagnosed malignancy. Mismatch repair (MMR), a proofreading machinery of the DNA, prevents tumorigenesis. The role of MMR deficiency in UCUB in eastern Indian population is not known.
Methods: Immunohistochemistry panel for MLH1, PMS2, MSH2, and MSH6 (MMR proteins) was performed on the biopsy specimens of UCUB (N=100).
Results: MMR deficiency by immunohistochemistry was demonstrated in two cases (2%). One case showed deficiency of MSH2 and MSH6 and the other case showed the deficiency of all four mismatch proteins. Both cases showed high-grade invasive urothelial carcinoma by histomorphology.
Conclusion: The prevalence of MMR deficiency by immunohistochemistry is 2% in eastern Indian population.
Department of Pathology and Lab Medicine, AIIMS, Bhubaneswar, Odisha
Source of Support: None, Conflict of Interest: None