Indian Journal of Cancer
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    -  Sadeghi R
    -  Saffari SE
    -  Hashemi Fard SM
    -  Aliakbarian M
 

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A meta-analysis of prognostic factors in patients with left-sided pancreatic cancer


1 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Centre for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, 8 College Road, Singapore
4 Department of Biology, Payame Noor University, Tehran, Iran

Correspondence Address:
Mohsen Aliakbarian,
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad
Iran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijc.IJC_1150_20

Background: Patients with ductal adenocarcinoma of the body and tail of the pancreas usually remain asymptomatic until late in the course of the disease, and the survival of such patients depends on multiple factors, which may affect the therapeutic approach and patient survival. Hence, the aim of this study was to investigate such risk factors by pooling various available studies. Methods: A systematic review was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines between January 1, 2007, and December 31, 2016, using the following databases: Medline, Scopus, the Cochrane Library, and Google Scholar. Studies were selected according to the predesigned eligibility criteria, and information was extracted for demographics, clinical features, and survival outcomes. Data were pooled using fixed- or random-effects models. Results: Sixteen studies were included (5,660 patients) with a median age of 64.8 years and a median survival of 28.5 (range 13–38) months. Identified significant factors for overall survival were higher age (hazard ratio [HR] = 1.211), men (HR = 1.182), presence of lymph node metastasis (HR = 1.964), multivisceral resection (HR = 1.947), N stage (1 versus 0; HR = 1.601), surgical margin (R0 versus No R0; HR = 0.519) and tumor size (>3 cm; HR = 1.890). Conclusion: The pooled results of this study revealed several risk factors for overall survival in patients with left-sided pancreatic cancer.




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