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Year : 2011  |  Volume : 48  |  Issue : 3  |  Page : 378-

Ki-67 as proliferative marker of thyroid

V Wiwanitkit 
 Wiwanitkit House, Bangkhae, Bangkok - 10160, Thailand

Correspondence Address:
V Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok - 10160

How to cite this article:
Wiwanitkit V. Ki-67 as proliferative marker of thyroid.Indian J Cancer 2011;48:378-378

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Wiwanitkit V. Ki-67 as proliferative marker of thyroid. Indian J Cancer [serial online] 2011 [cited 2021 Jan 22 ];48:378-378
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I read the recent report by Pujani et al. with a great interest. They concluded that "Ki-67 was found to be useful in differentiating between follicular adenoma and follicular carcinoma, but since the sample size of our study was small, larger studies are needed to confirm this observation as well as to assign a cutoff value for differentiating benign from malignant tumors." [1] As Pujani et al. noted, there are some limitations due to methodology of this report. Not only the few subjects but also no age and sex matched case control design are big problems that limit the clinical usefulness of this work. Indeed, there are also other left questions. The problems on the immunostaining of Ki-67 should also be discussed. False positive and false negative due to Ki- 67 tests are already reported in the study in colorectal cancer. [2]


1Pujani M, Arora B, Pujani M, Singh SK, Tejwani N. Role of Ki-67 as a proliferative marker in lesions of thyroid. Indian J Cancer 2010;47:304-7.
2Kuniyasu H, Oue N, Shigeishi H, Ito R, Kato Y, Yokozaki H, et al. Prospective study of Ki-67 labeling index in the mucosa adjacent to cancer as a marker for colorectal cancer metastasis. J Exp Clin Cancer Res 2001;20:543-8.