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Year : 2014  |  Volume : 51  |  Issue : 6  |  Page : 21--24

A meta-analysis of limb-salvage versus amputation in the treatment of patients with Enneking‡U pathologic fracture osteosarcoma

F Jiang1, Y Shi2, GJ Li1, F Zhou2 
1 Department of Orthopaedics, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, PR China
2 Department of Oncology, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, PR China

Correspondence Address:
Dr. Y Shi
Department of Oncology, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000
PR China

Introduction: The aim of this meta-analysis was to further explore whether the relapse, 5-year survival and metastasis the same or not between limb-salvage and amputation in the treatment of patients with limited stage Enneking‡U pathologic fracture osteosarcoma. Materials and Methods: An electronic search of the Medline, EMBASE and CNKI was done on October 2014. The clinical studies about amputation or limb-salvage surgery in the treatment of patients with limited stage Enneking‡U pathologic fracture osteosarcoma were searched and reviewed. The effect size of relapse, 5-year survival and metastasis between the amputation and limb-salvage surgery were pooled by stata11.0 software (Stata Corporation, College Station, TX, USA, http://www.stata.com;) using random or fixed effect model. The funnel plot and EggerSQs line regression test were used for evaluation of publication bias. Results: A total of 89 studies were identified and seven articles with 200 cases in the limb-salvage surgery group and 84 subjects in the amputation group were finally included in the meta-analysis. The pooled data indicated that no statistical different of risk for developing relapse between limb-salvage and amputation was found relative risk (RR) =1.40, 95% confidence interval (CI): 0.71-2.79, (P = 0.33). The 5-year survival rate of patients underwent limb-salvage surgery was smaller than patients received amputation RR = 1.86, 95%CI: 1.19-2.89, (P = 0.01); the metastasis rate of patients underwent limb-salvage surgery was significant decreased compared with patients received amputation RR = 0.56, 95% CI: 0.34-0.94, (P = 0.03). No publication bias was existed in this meta-analysis. Conclusion: Limb-salvage surgery does not increased the risk of relapse compared with amputation in the treatment of patients with limited stage Enneking‡U pathologic fracture osteosarcoma.


How to cite this article:
Jiang F, Shi Y, Li G J, Zhou F. A meta-analysis of limb-salvage versus amputation in the treatment of patients with Enneking‡U pathologic fracture osteosarcoma.Indian J Cancer 2014;51:21-24


How to cite this URL:
Jiang F, Shi Y, Li G J, Zhou F. A meta-analysis of limb-salvage versus amputation in the treatment of patients with Enneking‡U pathologic fracture osteosarcoma. Indian J Cancer [serial online] 2014 [cited 2022 Jan 18 ];51:21-24
Available from: https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2014;volume=51;issue=6;spage=21;epage=24;aulast=Jiang;type=0