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Year : 2015  |  Volume : 52  |  Issue : 7  |  Page : 144--147

The role of ppGalNAc-T family in breast cancer development and progression

R Yang, H Zhang, Y Ma, S Gong, J Niu, J Ma, A Zhong 
 Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou, China

Correspondence Address:
A Zhong
Department of Respiratory Medicine, Yidu Central Hospital of Weifang, Qingzhou
China

Glycosylation of proteins is an essential process in all eukaryotes. Mucin-type O-linked glycosylation is an evolutionarily conserved protein modification as a kind of glycosylation of proteins. The role of O-glycosylation was well documented in multiple cancers. While in breast cancer, the enzymes that catalyzed the initiation of O-glycosylation remained elusive. In this review, we briefly introduced the process of the initiation of O-glycosylation and summarized the roles of enzymes that catalyzed the initiation step of O-glycosylation in the breast cancer carcinogenesis, development, and progression. Finally, we summarized some attempts exploring the therapy against aberrant O-glycosylation.


How to cite this article:
Yang R, Zhang H, Ma Y, Gong S, Niu J, Ma J, Zhong A. The role of ppGalNAc-T family in breast cancer development and progression.Indian J Cancer 2015;52:144-147


How to cite this URL:
Yang R, Zhang H, Ma Y, Gong S, Niu J, Ma J, Zhong A. The role of ppGalNAc-T family in breast cancer development and progression. Indian J Cancer [serial online] 2015 [cited 2021 Jun 19 ];52:144-147
Available from: https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2015;volume=52;issue=7;spage=144;epage=147;aulast=Yang;type=0