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Year : 2021  |  Volume : 58  |  Issue : 2  |  Page : 278--284

Secretory carcinoma of salivary gland origin: A recently established masquerader

Shilpi Budhiraja1, Rajeev Kumar1, Gaurav Khanna2, Prem Sagar1, Sudhir Arava2, Adarsh Barwad2, Asit Ranjan Mridha2 
1 Department of Otolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, New Delhi, India
2 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Prem Sagar
Department of Otolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, New Delhi
India

Secretory carcinoma (SC) of the salivary gland is considered to be a low-intermediate grade tumor with the potential of locally aggressive behavior. This tumor is similar both genetically (ETV6-NTRK3 fusion) and histologically to secretory carcinoma of the breast. We intent to share our experience of four cases of SC in terms of clinical behavior, pathological features, and treatment outcome. Medical records of four cases of SC were retrieved and analyzed for clinical presentation, surgical treatment, and outcome. Pathological data was reanalyzed along with immunohistochemistry. Out of the four identified SC cases, three were men. Two lesions originated from the parotid gland and two from minor salivary glands. Two of these cases exhibited features of locally aggressive pattern. SC of salivary gland origin has distinct histological and immunohistochemical features apart from the characteristic genetic translocation and fusion. Surgery with or without adjuvant radiotherapy is the treatment of choice. To establish the biological behavior of this tumor, larger case series with long-term follow-up is desirable.


How to cite this article:
Budhiraja S, Kumar R, Khanna G, Sagar P, Arava S, Barwad A, Mridha AR. Secretory carcinoma of salivary gland origin: A recently established masquerader.Indian J Cancer 2021;58:278-284


How to cite this URL:
Budhiraja S, Kumar R, Khanna G, Sagar P, Arava S, Barwad A, Mridha AR. Secretory carcinoma of salivary gland origin: A recently established masquerader. Indian J Cancer [serial online] 2021 [cited 2021 Aug 1 ];58:278-284
Available from: https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2021;volume=58;issue=2;spage=278;epage=284;aulast=Budhiraja;type=0