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Year : 2022  |  Volume : 59  |  Issue : 2  |  Page : 279--281

Expression of mismatch repair proteins in urothelial carcinoma of the urinary bladder

Rasheeda Mohamedali1, Amit K Adhya1, Swarnendu Mandal2, Suvradeep Mitra1 
1 Department of Pathology and Lab Medicine, AIIMS, Bhubaneswar, Odisha, India
2 Department of Urology, AIIMS, Bhubaneswar, Odisha, India

Correspondence Address:
Suvradeep Mitra
Department of Pathology and Lab Medicine, AIIMS, Bhubaneswar, Odisha
India

Background: Urothelial carcinoma of the urinary bladder (UCUB) is a frequently diagnosed malignancy. Mismatch repair (MMR), a proofreading machinery of the DNA, prevents tumorigenesis. The role of MMR deficiency in UCUB in eastern Indian population is not known. Methods: Immunohistochemistry panel for MLH1, PMS2, MSH2, and MSH6 (MMR proteins) was performed on the biopsy specimens of UCUB (N=100). Results: MMR deficiency by immunohistochemistry was demonstrated in two cases (2%). One case showed deficiency of MSH2 and MSH6 and the other case showed the deficiency of all four mismatch proteins. Both cases showed high-grade invasive urothelial carcinoma by histomorphology. Conclusion: The prevalence of MMR deficiency by immunohistochemistry is 2% in eastern Indian population.


How to cite this article:
Mohamedali R, Adhya AK, Mandal S, Mitra S. Expression of mismatch repair proteins in urothelial carcinoma of the urinary bladder.Indian J Cancer 2022;59:279-281


How to cite this URL:
Mohamedali R, Adhya AK, Mandal S, Mitra S. Expression of mismatch repair proteins in urothelial carcinoma of the urinary bladder. Indian J Cancer [serial online] 2022 [cited 2022 Dec 7 ];59:279-281
Available from: https://www.indianjcancer.com/article.asp?issn=0019-509X;year=2022;volume=59;issue=2;spage=279;epage=281;aulast=Mohamedali;type=0