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2015| April-June | Volume 52 | Issue 2
Online since
February 5, 2016
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SYMPOSIUM - MOLECULAR ONCOLOGY: REVIEW ARTICLES
Design, architecture and application of nanorobotics in oncology
S Saxena, BJ Pramod, BC Dayananda, K Nagaraju
April-June 2015, 52(2):236-241
DOI
:10.4103/0019-509X.175805
PMID
:26853420
Oncologists all over the globe, relentlessly research on methodologies for detection of cancer and precise localization of cancer therapeutics with minimal adverse effects on healthy tissues. Since the previous decade, the fast growing research in nanotechnology has shown promising possibilities for achieving this dream of every oncologist.Nanorobots (or nanobots) are typical devices ranging in size from 0.1 to 10 μm and constructed of nanoscale or molecular components. Robots will augment the surgeon's motor performance, diagnostic capability and sensations with haptics and augmented reality. The article here aims in briefly describing the architecture of the nanorobots and their role in oncotherapy. Although, research into nanorobots is still in its preliminary stages, the promise of such technology is endless.
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SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: REVIEW ARTICLES
Nutritional assessment and intervention in a pediatric oncology unit
J Schoeman
April-June 2015, 52(2):186-190
DOI
:10.4103/0019-509X.175832
PMID
:26853397
Nutritional status in children with cancer is an important prognostic factor. Assessment consisting of anthropometry, biochemistry, clinical, and diet that needs to be done on diagnosis and regularly to ensure that patient's nutritional status does not deteriorate. In developing countries, assessment will depend on the availability of all resources, but monitoring is essential. The development of malnutrition during treatment is possible and the reasons are multifactorial. Nutrition plays a deciding role and a key factor in children with cancer and can influence their outcome.
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Importance of nutrition in pediatric oncology
PC Rogers
April-June 2015, 52(2):176-178
DOI
:10.4103/0019-509X.175830
PMID
:26853391
A nutritional perspective within pediatric oncology is usually just related to the supportive care aspect during the management of the underlying malignancy. However, nutrition has a far more fundamental importance with respect to a growing, developing child who has cancer as well as viewing cancer from a nutritional cancer control perspective. Nutrition is relevant to all components of cancer control including prevention, epidemiology, biology, treatment, supportive care, rehabilitation, and survivorship. This article briefly describes this perspective of nutrition within a cancer control context and is a summary of the presentation at the “1
st
International SIOP-PODC Workshop on Nutrition in Children with Cancer” held in Mumbai.
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SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: ORIGINAL ARTICLES
Nutritional status at presentation, comparison of assessment tools, and importance of arm anthropometry in children with cancer in India
P Shah, U Jhaveri, TB Idhate, S Dhingra, P Arolkar, B Arora
April-June 2015, 52(2):210-215
DOI
:10.4103/0019-509X.175838
PMID
:26853408
Background:
In India, approximately 40,000 new cases of cancer in children are diagnosed each year. However, there are no good studies analyzing their nutritional status. Also, since accurate and sensitive nutritional assessment is critical for optimal clinical outcomes through timely remediation of malnutrition, it is important to assess the relative sensitivity and feasibility of commonly used nutritional screening tools.
Methods:
This observational study analyzed height/length (cm), weight (kg), mid-upper arm circumference (MUAC), triceps skinfold thickness (TSFT) as well as their Z-scores or percentiles, albumin levels and history of weight loss at diagnosis in children aged 2–15 years being treated for cancer between November 2008 to December 2013. Body mass index (BMI) and arm muscle circumference (AMC) were calculated respectively from height and weight, and MUAC and TSFT.
Results:
A total of 1693 new patients were enrolled; 1187 had all anthropometric measurements performed. The prevalence of malnutrition was 38%, 57%, 76%, 69% and 81% on the basis of BMI, TSFT, MUAC, AMC, and arm TSFT + MUAC respectively with the highest prevalence in solid abdominal tumours. Addition of BMI and serum albumin to arm anthropometry increased the proportion classified as severely nutritionally depleted by a mere 2% & 1.5% respectively. Positive history of significant weight loss additionally identified 16.5% at nutritional risk over arm anthropometry.
Conclusions:
The prevalence of malnutrition in Indian children with cancer at presentation is very high ranging from 40% and 80% depending on the method used for assessment, being higher with MUAC and lowest with BMI. Either MUAC alone or TSFT + MUAC (wherever feasible) should be used for screening for malnutrition in children with cancer at diagnosis to plan timely nutritional interventions, reduce the treatment-related morbidity and optimise their chance of long-term cure.
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SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: REVIEW ARTICLES
Nutritional status in children with cancer: Before, during and after therapy
RD Barr
April-June 2015, 52(2):173-175
DOI
:10.4103/0019-509X.175827
PMID
:26853390
Context:
Malnutrition is prevalent in children with cancer at diagnosis, especially in low- and middle-income countries (LMIC) where the great majority of children live. It is associated with an added burden of morbidity and mortality.
Aims:
Answers were sought to the best measure of nutritional status in LMIC, the impact of anti-neoplastic therapy, effective interventions to achieve normal nutritional status and the impact of these on clinical outcomes.
Results:
Arm anthropometry offers reasonable estimates of fat mass and lean body mass that are both impacted adversely by treatment. Nutritional supplementation, including the use of simple local resources, is beneficial and can improve survival. Long-term survivors may continue to exhibit perturbed nutritional status.
Conclusions:
The prevalence and severity of malnutrition in children with cancer in LMIC demand attention. Opportunities exist to conduct studies in India to examine the effects of nutritional interventions, including on the overall well-being of survivors.
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Parenteral and enteral nutrition for pediatric oncology in low- and middle-income countries
K Viani
April-June 2015, 52(2):182-184
DOI
:10.4103/0019-509X.175837
PMID
:26853395
Although nutritional therapy is essential for the treatment of childhood cancer, it remains a challenge, especially within the developing world, where there are many barriers to optimizing treatment. The oral route is the first approach to nutritional support, however challenging this might be in children with cancer. Oral supplements are indicated in moderate evaluated nutritional risk patients and its use should consider the family's social conditions and access to industrialized oral supplements. If unavailable, homemade oral supplements can be used respecting regional accessibility, local foods, and culture. Nonetheless, many patients cannot sustain nutritional status on oral feeding alone and need to be supported by enteral tube feeding. Enteral feeding may be modified to accommodate the financial constraints of institution in low- and middle-income countries (LMICs). In some oncologic situations, however, enteral nutrition is not possible and parenteral nutrition is indicated, although only if the need for nutritional support is anticipated to be longer than 5–7 days. Nutritional support in pediatric oncology remains a challenge, especially in LMICs, however, it can be undertaken by getting the best out of the available resources.
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SYMPOSIUM - MOLECULAR ONCOLOGY: ORIGINAL ARTICLES
Genomic profiling in a homogeneous molecular subtype of non-small cell lung cancer: An effort to explore new drug targets
Vidya H Veldore, S Patil, CT Satheesh, HP Shashidhara, R Tejaswi, Shilpa A Prabhudesai, N Krishnamoorthy, D Hazarika, R Naik, Raghavendra M Rao, BS Ajai Kumar
April-June 2015, 52(2):243-248
DOI
:10.4103/0019-509X.175843
PMID
:26853422
Background:
Patients' who are positive for kinase domain activating mutations in epidermal growth factor receptor (EGFR) gene, constitute 30–40% of non-small cell lung cancer (NSCLC), and are suitable candidates for Tyrosine Kinase Inhibitor based targeted/personalized therapy. In EGFR non-mutated subset, 8–10% that show molecular abnormalities such as EML4-ALK, ROS1-ALK, KIP4-ALK, may also derive the benefit of targeted therapy. However, 40% of NSCLC belong to a grey zone of tumours that are negative for the clinically approved biomarkers for personalized therapy. This pilot study aims to identify and classify molecular subtypes of this group to address the un-met need for new drug targets in this category. Here we screened for known/novel oncogenic driver mutations using a 46 gene Ampliseq Panel V1.0 that includes Ser/Thr/Tyr kinases, transcription factors and tumor suppressors.
Methods:
NSCLC with tumor burden of at least 40% on histopathology were screened for 29 somatic mutations in the EGFR kinase domain by real-time polymerase chain reaction methods. 20 cases which were EGFR non-mutated for TK domain mutations were included in this study. DNA Quality was verified from each of the 20 cases by fluorimeter, pooled and subjected to targeted re-sequencing in the Ion Torrent platform. Torrent Suite software was used for next generation sequencing raw data processing and variant calling.
Results:
The clinical relevance and pathological role of all the mutations/variants that include SNPs and Indels was assessed using polyphen-2/SIFT/PROVEAN/mutation assessor structure function prediction programs. There were 10 pathogenic mutations in six different oncogenes for which annotation was available in the COSMIC database; C420R mutation in PIK3CA, Q472H mutation in vascular endothelial growth factor receptor 2 (VEGFR2) (KDR), C630W and C634R in RET, K367M mutation in fibroblast growth factor receptor 2 (FGFR2), G12C in KRAS and 4 pathogenic mutations in TP53 in the DNA binding domain (E285K, R213L, R175H, V173G).
Conclusion:
Results suggest, a potential role for PIK3CA, VEGFR2, RET and FGFR2 as therapeutic targets in EGFR non-mutated NSCLC that requires further clinical validation.
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SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: ORIGINAL ARTICLES
Indicators of malnutrition in children with cancer: A study of 690 patients from a tertiary care cancer center
R Srivastava, D Pushpam, D Dhawan, S Bakhshi
April-June 2015, 52(2):199-201
DOI
:10.4103/0019-509X.175825
PMID
:26853403
Background:
Large data pertaining to indicators of malnutrition in children with cancer is lacking from India. In view of this, we prospectively analyzed consecutive
de novo
childhood patients with cancer presenting at a tertiary care center.
Materials And Methods:
Height and weight of each child (
n
= 690) were compared with World Health Organization child growth standards-2006 for that particular age and sex to get weight-for-age, height-for-age, and weight-for-height indices and below 2SD of the reference median on these indices were considered as underweight, stunted, and wasted, respectively. Body mass index (BMI) for age was also analyzed for thinness and obesity.
Results:
Prevalence of malnutrition based on Z-score for weight-for-age, height-for-age, weight-for-height, and BMI-for-age was 30%, 31%, 35%, and 41%, respectively. Weight-for-age (underweight) was significantly associated (
P
= 0.018) with solid tumors. Height-for-age, weight-for-age, and BMI-for-age were significantly associated (
P
= 0.007,
P
= 0.016, and
P
≤ 0.001, respectively) with rural community.
Conclusion:
Malnutrition was observed in approximately one-third of children with cancer. Malnutrition is associated with solid tumors and those coming from rural community. Wasting has a higher prevalence in children with cancer in <5 years of age group.
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A survey of nutritional practices for children with cancer in India
A Sharma, EF Negi, B Arora, D Pradhan, M Khurana, P Bagai, RS Arora
April-June 2015, 52(2):191-193
DOI
:10.4103/0019-509X.175831
PMID
:26853399
Background:
Assessing nutritional status and delivering optimal nutritional care is a part of modern day treatment of children with cancer. The nutritional practices in India for these children have not been previously described.
Aims:
To describe the existing nutrition assessment and management practices for children with cancer in India.
Methods:
Attendees of the First International Society of Pediatric Oncology-Pediatric Oncology in Developing Countries workshop on nutrition in children with cancer organized in September 2014 at Tata Memorial Hospital, Mumbai, India were invited to complete a self-administered questionnaire related to three domains: nutritional assessment, intervention, and education.
Results:
Hundred and eight respondents from 42 health institutions and background in the health sector participated in the survey. There was variability in nutritional assessment, practice and education. Lack of resources and time are contributory.
Conclusions:
This assessment of nutritional services in India provided useful information to plan development of national guidelines, policy, and delivery of services.
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Nutritional profile of pediatric cancer patients at Cancer Institute, Chennai
V Radhakrishnan, P Ganesan, R Rajendranath, TS Ganesan, TG Sagar
April-June 2015, 52(2):207-209
DOI
:10.4103/0019-509X.175841
PMID
:26853406
Background:
Malnutrition is widely prevalent in the pediatric population in India. There is paucity of data on the prevalence of malnutrition in pediatric cancer patients and the impact of cancer treatment on nutritional status of Indian children.
Aims:
The study was conducted to look at the prevalence of malnutrition and assess the impact of treatment on nutritional status of pediatric cancer patients.
Settings And Design:
This was a retrospective study.
Materials And Methods:
Data on the weight of pediatric cancer patients <16 years of age treated at Cancer Institute, Chennai, from January 2013 to May 2014 were analyzed at systematic time points in therapy. Patients' weight were plotted on the Centre for Disease Control (CDC) growth charts. Patients were defined to be undernourished if their weight for age was ≤3
rd
centile in CDC growth charts and obese if their weight for age was ≥97
th
centile on CDC growth charts.
RESULTS:
A total of 295 patient case records were analyzed. Acute lymphoblastic leukemia was the most common malignancy. At diagnosis, under-nutrition was seen in 44% patients, this increased to 46% midway during treatment (end of induction in acute leukemia and completion of 50% of planned treatment in solid tumors) and decreased to 27% at the end of treatment (beginning of maintenance in acute leukemia and completion of planned treatment in solid tumors) (
P
= 0.0005). There was no significant difference in nutritional status between patients with hematological malignancies and solid tumors (
P
= 0.8).
Conclusion:
Under-nutrition is present in close to half of the pediatric cancer patients presenting to our institute. Active nutritional intervention and education were able to significantly reduce the prevalence of under-nutrition in patients at the end of treatment.
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LETTERS TO THE EDITOR
Primary undifferentiated spindle cell sarcoma of the lung with metastasis to bone - A rare clinical entity with even rarer clinical course
A Gulia, A Puri, B Rekha, CS Pramesh
April-June 2015, 52(2):254-255
DOI
:10.4103/0019-509X.175839
PMID
:26853426
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SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: REVIEW ARTICLES
Approach to metabolic syndrome in childhood cancer survivors
JX Scott, MS Latha, R Aruna
April-June 2015, 52(2):169-172
DOI
:10.4103/0019-509X.175840
PMID
:26853389
The combined effects of optimized chemotherapy, surgery, radiotherapy, stem cell transplantation regimens, and improved supportive care had drastically increased the survival rate of childhood cancer. Hence, the number of adult survivors of childhood cancer is on the raise and this subset of population is gaining more attention due to the late effects of their cancer therapy. There is growing evidence that pediatric cancer survivors are at a greater risk of developing metabolic syndrome (MS) or the MS component traits than the general population. There is currently no drug therapy to treat MS as a whole disease, as it is a cluster of symptoms that present uniquely among different individuals. Given the recent recognition of MS in adult survivors of childhood cancer, there is a scarcity of long-term follow-up studies of this group. Adherence to a healthy lifestyle with both dietary and physical activity is the only most powerful and most useful armor available now against obesity and its metabolic complications.
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3,706
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SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: ORIGINAL ARTICLES
The development, testing, and preliminary feasibility of an adaptable pediatric oncology nutrition algorithm for low-middle income countries
CAK Fleming, K Viani, AJ Murphy, TT Mosby, B Arora, J Schoeman, EJ Ladas
April-June 2015, 52(2):225-228
DOI
:10.4103/0019-509X.175834
PMID
:26853414
Background:
Survivors of childhood cancer are at increased risk for several cardiometabolic complications. Obesity/overweight and metabolic syndrome have been widely reported in Western literature, but data from India are lacking.
Aims:
To perform an objective assessment of nutritional status in a cohort of childhood cancer survivors (CCSs) and to find risk factors for extremes in nutritional status.
Settings And Design:
The study was a retrospective chart review of CCSs who attended the late effects clinic of a referral pediatric oncology center over the period of 1 year.
Materials And Methods:
An objective assessment of nutritional status was done, and results were analyzed in two groups: Adult survivors (present age <18 years) and child and adolescent survivors (CASs) (<18 years). The data were then analyzed for possible risk factors.
Results:
Six hundred and forty-eight survivors were included in the study; of these, 471 were <18 years at follow-up, and 177 were 18 years or older. The prevalence of obesity, overweight, normal, and undernutrition was 2.6%, 10.8%, 62.7%, and 28.8% (CASs) and 0%, 8.5%, 62.7%, and 28.8% (adult survivors), respectively. Factors predictive of overweight/obesity were an initial diagnosis of acute lymphoblastic leukemia, or brain tumor and follow-up duration of >20 years or current age >30 years in adult survivors.
Conclusions:
The prevalence of obesity/overweight is lower in our cohort when compared to Western literature. It remains to be clarified whether this reflects the underlying undernutrition in our country, or whether our cohort of survivors is indeed distinct from their Western counterparts. Comparison with age/sex-matched normal controls and baseline parameters would yield more meaningful results.
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Nutritional status in survivors of childhood cancer: Experience from Tata Memorial Hospital, Mumbai
M Prasad, B Arora, G Chinnaswamy, T Vora, G Narula, S Banavali, P Kurkure
April-June 2015, 52(2):219-223
DOI
:10.4103/0019-509X.175814
PMID
:26853412
Background:
Survivors of childhood cancer are at increased risk for several cardiometabolic complications. Obesity/overweight and metabolic syndrome have been widely reported in Western literature, but data from India are lacking.
Aims:
To perform an objective assessment of nutritional status in a cohort of childhood cancer survivors (CCSs) and to find risk factors for extremes in nutritional status.
Settings And Design:
The study was a retrospective chart review of CCSs who attended the late effects clinic of a referral pediatric oncology center over the period of 1 year.
Materials And Methods:
An objective assessment of nutritional status was done, and results were analyzed in two groups: Adult survivors (present age <18 years) and child and adolescent survivors (CASs) (<18 years). The data were then analyzed for possible risk factors.
Results:
Six hundred and forty-eight survivors were included in the study; of these, 471 were <18 years at follow-up, and 177 were 18 years or older. The prevalence of obesity, overweight, normal, and undernutrition was 2.6%, 10.8%, 62.7%, and 28.8% (CASs) and 0%, 8.5%, 62.7%, and 28.8% (adult survivors), respectively. Factors predictive of overweight/obesity were an initial diagnosis of acute lymphoblastic leukemia, or brain tumor and follow-up duration of >20 years or current age >30 years in adult survivors.
Conclusions:
The prevalence of obesity/overweight is lower in our cohort when compared to Western literature. It remains to be clarified whether this reflects the underlying undernutrition in our country, or whether our cohort of survivors is indeed distinct from their Western counterparts. Comparison with age/sex-matched normal controls and baseline parameters would yield more meaningful results.
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SYMPOSIUM - MOLECULAR ONCOLOGY: REVIEW ARTICLES
Circulating tumor cells in oral squamous cell carcinoma: An insight
BV Prakruthi, NC Babu
April-June 2015, 52(2):232-234
DOI
:10.4103/0019-509X.175844
PMID
:26853418
Circulating tumor cells (CTCs) are those cells present in the blood and have antigenic and/or genetic characteristics of a specific tumor type. CTCs can be detected in the peripheral blood of cancer patients. Various techniques are available for detection of CTCs, which provide evidence for future metastasis. CTCs may provide new insight into the biology of cancer and process of metastasis in oral squamous cell carcinoma (OSCC). The detection of CTCs may represent a new diagnostic tool for predicting the occurrence of metastatic disease in OSCC and endow with the treatment strategies to efficiently treat and prevent cancer metastasis. This review gives an insight into the significance of CTCs and different techniques for detection of CTCs.
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3,143
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1
SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: EDITORIAL
International nutrition capacity building - A global SIOP-PODC model from India
B Arora, EJ Ladas
April-June 2015, 52(2):163-166
DOI
:10.4103/0019-509X.175836
PMID
:26853386
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8
SYMPOSIUM - 1ST INTERNATIONAL SIOP-PODC NUTRITION WORKSHOP: ORIGINAL ARTICLES
The impact of weight for age on survival in acute lymphoblastic leukemia: Report from a tertiary care center in North India
A Trehan, V Prabhu, D Bansal
April-June 2015, 52(2):203-206
DOI
:10.4103/0019-509X.175835
PMID
:26853405
Background:
Undernutrition is considered to have a negative impact on survival in children with malignancies. The objective of this retrospective analysis was to evaluate the morbidity pattern and outcome of therapy in undernourished (UN) children with acute lymphoblastic leukemia.
Methods:
A retrospective analysis of impact of weight for age was performed in children treated for ALL. The IAP & CDC criteria for undernutrition were used in the two different time periods of analysis.
Results:
There were two cohorts in the study: Between 1995 and 2005, 360 children were evaluated where the weight for age was classified using the Indian Academy of Pediatrics criteria for undernourishment (Group A). Group B of the study included 373 children treated from 2007 to 2011, who were graded as per the Centers for Disease Control criteria for weight for age. In Group A, 35% of the children were malnourished at presentation. The morbidity and supportive care needed in the well-nourished and UN group were similar. The event-free survival and mortality were similar in both groups. Analysis of Group B showed an overall survival of 62.6% with a greater survival in children with a weight of ≥10
th
centile for age compared to children at the <10
th
centile, (
P
= 0.026) with a higher mortality (
P
= 0.011) in the UN group.
Conclusion:
Our data have yielded conflicting results. The older cohort did not show a significant difference in survival using malnutrition as a risk factor. However, in the subsequent cohort, a difference in survival was noted. This could be due to the reason that different criteria for classification of undernutrition were applied in the two groups. This analysis lays the foundation for a future prospective analysis to evaluate nutrition as an independent risk factor nutrition as an independent risk factor in the outcome of childhood malignancies.
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2
Adiponectin correlates with obesity: A study of 159 childhood acute leukemia survivors from India
R Srivastava, A Batra, A Tyagi, D Dhawan, L Ramakrishnan, S Bakhshi
April-June 2015, 52(2):195-197
DOI
:10.4103/0019-509X.175824
PMID
:26853401
Background:
Acute lymphoblastic leukemia survivors are predisposed to obesity. However, the exact underlying mechanisms are not known.
AIMS:
The study was done to assess the role of biomarkers of obesity in acute leukemia survivors.
Settings And Designs:
This is a cross-sectional study conducted at All India Institute of Medical Sciences in survivors of acute leukemia who had completed treatment at least 1 year before enrollment in this study.
Materials And Methods:
Obesity was studied by determining the body mass index. Potential biomarkers were studied by assessing serum leptin, resistin, and adiponectin by enzyme-linked immunosorbant assay, and the results were compared in obese versus nonobese survivors.
Statistical Analysis:
Descriptive analysis for baseline demographic factors and Student's
t
-test for comparing the mean levels of biomarkers among the obese and nonobese survivors.
Results:
One hundred and fifty-nine acute leukemia patients were enrolled in this study with a median follow-up of 36.8 months. The median age was 10 (range: 3–18) years, and 123 (77.3%) patients were males. The overall prevalence of overweight/obesity was 26.4%, and this was similar in acute myeloid leukemia and acute lymphoblastic leukemia sub-groups (26.2% vs. 27.3%,
P
= 0.9). Mean serum leptin and resistin were similar in obese and nonobese leukemia survivors (3.7 vs. 2.85 pg/mL,
P
= 0.064; 8.01 vs. 9.33 ng/mL,
P
= 0.36). However, mean serum adiponectin was significantly lower in obese leukemia survivors (7.97 vs. 11.5 μg/mL,
P
= 0.023).
Conclusions:
Obese leukemic survivors had lower serum adiponectin levels than nonobese survivors. However, serum resistin and leptin levels were similar in the two groups.
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7
LETTERS TO THE EDITOR
T-cell chronic lymphocytic leukemia/T-prolymphocytic leukemia: Experience with single agent bendamustine
NK Thota, Gundeti Sadashivudu, Linga Vijay Gandhi, Coca Pragnya, T Paul Roshni, Digumarti Raghunadharao
April-June 2015, 52(2):193-194
DOI
:10.4103/0019-509X.175812
PMID
:26853400
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2,692
187
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Teaching pathology of breast cancer to medical undergraduates by case based learning method
N Kapoor
April-June 2015, 52(2):215-216
DOI
:10.4103/0019-509X.175819
PMID
:26853409
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2,315
209
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Hypothesizing association between cancer cachexia and Fluorodeoxyglucose-positron emission tomography documented brown adipose tissue hypermetabolism in cancer patients with an illustration in grossly emaciated cachectic patient in hot Indian summer climate: Will beta blockers find use in the management of this condition?
S Basu
April-June 2015, 52(2):223-224
DOI
:10.4103/0019-509X.175828
PMID
:26853413
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2,271
230
2
Ubiquitous lytic osseous lesions in acute lymphoblastic leukemia: A rare case report
V Annam, P Raghuram, DS Vasudeva, HT Narayana
April-June 2015, 52(2):228-229
DOI
:10.4103/0019-509X.175821
PMID
:26853415
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157
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Carcinoma and tuberculosis of the breast coexisting in same breast with axillary lymphadenopathy: A rare association
A Bansal, V Sipayya, C Chintamani, S Saxena
April-June 2015, 52(2):229-230
DOI
:10.4103/0019-509X.175818
PMID
:26853416
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2,261
181
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Ameloblastic carcinoma: An effort to abridge this diagnostic challenge!
S Routray, S Majumdar, N Swain
April-June 2015, 52(2):234-235
DOI
:10.4103/0019-509X.175823
PMID
:26853419
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2,199
196
1
SYMPOSIUM - MOLECULAR ONCOLOGY: ORIGINAL ARTICLES
Heterozygosity of stromelysin-1 (rs3025058) promoter polymorphism is associated with gastric cancer
D Krishnaveni, AC Bhayal, KP Shravan, A Jyothy, N Pratibha, A Venkateshwari
April-June 2015, 52(2):251-254
DOI
:10.4103/0019-509X.175806
PMID
:26853425
Background:
Gastric cancer (GC) is the third most common cancer in India and is mediated by multiple genetic, epigenetic and environmental risk factors. A single nucleotide polymorphism rs3025058 at − 1171 of the stromelysin-1 (matrix metalloproteinase [MMP]-3) promoter is resulting due to insertion/deletion of adenine thought to have an impact on increasing the risk for tumor formation.
Aim:
This study is aimed to understand the role of stromelysin-1 rs3025058 (−1171, 5A/6A) promoter polymorphism in the etiology of GC in Indian population.
Materials And Methods:
Genomic DNA was isolated from blood samples of the GC patients and controls. The genotyping of stromelysin-1 rs3025058 (−1171, 5A/6A) promoter polymorphism was carried out by amplification refractory mutation system-polymerase chain reaction method followed by agarose gel electrophoresis.
RESULTS:
The frequency of 5A/5A, 5A/6A, and 6A/6A genotypes in GC patients were 7.69%, 76.92%, and 15.38%, while in controls were 5.31%, 86.73%, and7.96%, respectively. There was a significant difference in the distribution of 5A/6A genotype in patients compared to the controls (P < 0.05).
Conclusion:
This study showed an increased frequency of heterozygotes for stromelysin-1 rs3025058 and thought to be involved in the etiology of GC.
[ABSTRACT]
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2,176
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LETTERS TO THE EDITOR
Non-Hodgkin's lymphoma of the infratemporal fossa: A case report
AK Giri, GV Vishnu Vardhan, KK Bassi, S Giri
April-June 2015, 52(2):178-179
DOI
:10.4103/0019-509X.175804
PMID
:26853392
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2,143
170
1
Mesenteric adenopathy and malignant ascites in prostatic adenocarcinoma: An unusual presentation
MR Pradhan, K Pradhan, R Kapoor
April-June 2015, 52(2):217-218
DOI
:10.4103/0019-509X.175816
PMID
:26853411
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2,163
127
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Synovial sarcoma of the omentum: A rare entity
G Indranil, M Divya
April-June 2015, 52(2):166-167
DOI
:10.4103/0019-509X.175842
PMID
:26853387
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1,997
198
1
Triple negative epithelial ovarian cancer: “A new entity”
P Jain, A Jain, B Dubashi
April-June 2015, 52(2):190-190
DOI
:10.4103/0019-509X.175811
PMID
:26853398
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1,994
173
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The inside mystery of penile leiomyosarcoma
Anil Kumar Dhull, Vivek Kaushal, Satish Dalal, Sunita Singh
April-June 2015, 52(2):241-242
DOI
:10.4103/0019-509X.175826
PMID
:26853421
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2,006
136
1
Could ingenol mebutate be useful in managing nonmelanoma skin cancers?
PR Bhandari, VV Pai
April-June 2015, 52(2):249-250
DOI
:10.4103/0019-509X.175820
PMID
:26853424
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1,975
159
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Metastasis to bilateral breasts from maxillary embryonal rhabdomyosarcoma demonstrated on F-18 FDG PET/CECT
M Tripathi, S Mahajan, S Nanda, M D’Souza, JS Bhalla
April-June 2015, 52(2):167-168
DOI
:10.4103/0019-509X.175809
PMID
:26853388
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1,856
172
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Utility of ultrasonic scalpel for axillary dissection in a patient with permanent cardiac pacemakers
M Sabaretnam, A Mishra
April-June 2015, 52(2):209-209
DOI
:10.4103/0019-509X.175822
PMID
:26853407
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1,801
196
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Pneumocytic adenomyoepithelioma in a case of myoepithelial carcinoma of the submandibular gland
A Krishnamurthy, A Vaidhyanathan, U Majhi
April-June 2015, 52(2):216-217
DOI
:10.4103/0019-509X.175813
PMID
:26853410
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1,833
161
2
Ileocaecal Metastasis from Carcinoma Cervix presenting with bowel obstruction: A rare case report
M Choudhury, S Singh, V Puri, M Nain
April-June 2015, 52(2):179-180
DOI
:10.4103/0019-509X.175808
PMID
:26853393
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1,733
152
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Carcinoma of the gallbladder presenting with multiple osseous and inguinal lymph node metastases
A Joel, A Samuel, A Bhatt, A Chandramohan, RT Chacko
April-June 2015, 52(2):230-231
DOI
:10.4103/0019-509X.175829
PMID
:26853417
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1,657
156
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OrthOncoCon-2014: Continuing education in musculoskeletal oncology
A Gulia, C Wilding, MB Suman, A Puri
April-June 2015, 52(2):184-185
DOI
:10.4103/0019-509X.175810
PMID
:26853396
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1,639
149
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Invasion of lung cancer into breast: The first case report
D Unal, A Oguz, A Tasdemir, A Koc
April-June 2015, 52(2):197-198
DOI
:10.4103/0019-509X.175815
PMID
:26853402
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1,621
154
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Trends of reported cases of retinoblastoma post-enucleation seeking prosthetic rehabilitation: Few annotations
H Aggarwal, P Kumar
April-June 2015, 52(2):180-181
DOI
:10.4103/0019-509X.175807
PMID
:26853394
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1,610
156
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Bone-confined extensive disease as the presentation of disease recurrence in the setting of malignant transformation of pleomorphic adenoma of parotid gland with excellent locoregional control: Value of whole body skeletal survey
S Basu, T Shet
April-June 2015, 52(2):248-249
DOI
:10.4103/0019-509X.175833
PMID
:26853423
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1,511
133
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Three squamous cell carcinomas of different sites in three years: A mere coincidence?
Mawaddah Azman, Mohd Razif Mohd Yunus
April-June 2015, 52(2):201-202
DOI
:10.4103/0019-509X.175817
PMID
:26853404
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1,486
129
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