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Figure 2: a: ATPase activity of ABCG2 pump-concentration of nilotinib required to overcome resistance to ABCG2 is lower than that of imatinib. Adopted from Brendel et al.[12] Figure 2: b: CML cell line apoptosis with imatinib and nilotinib is influenced by ABCG2 inhibitor FTC. Note that the concentration of nilotinib required to kill CML cells is much less than that of imatinib. Adapted from Brendel et al.[12]

Figure 2: a: ATPase activity of ABCG2 pump-concentration of nilotinib required to overcome resistance to ABCG2 is lower than that of imatinib. Adopted from Brendel <i>et al.</i><sup>[12]</sup>
Figure 2: b: CML cell line apoptosis with imatinib and nilotinib is influenced by ABCG2 inhibitor FTC. Note that the concentration of nilotinib required to kill CML cells is much less than that of imatinib. Adapted from Brendel <i>et al.</i><sup>[12]</sup>