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Figure 1: The JAK2V617F mutation involves a G to T alteration in the pseudokinase domain of JAK. This results in a valine-to-phenyl alanine substitution at codon 617 that disrupt its auto-inhibitory activity and leads to constitutive kinase activity that leads to cytokine-independent growth in hematopoietic cells

Figure 1: The JAK2V617F mutation involves a G to T alteration in the pseudokinase domain of JAK. This results in a valine-to-phenyl alanine substitution at codon 617 that disrupt its auto-inhibitory activity and leads to constitutive kinase activity that leads to cytokine-independent growth in hematopoietic cells