Indian J Pharm Close
 

Figure 8: VEGF-A (vascular endothelial growth factor-A) expressing cancer cells induce tumor and lymph node (LN) lymphangiogenesis. In normal skin, lymphatic vessels are present in the dermis and maintain tissue fluid homeostasis. There is no detectable lymphangiogenesis within draining LN. squamous cell carcinoma (SCC) of K14/VEGF-A-transgenic mice induce primary, tumor-associated, lymphatic vessel growth but also lymphangiogenesis within sentinel lymph node (SLN), even before they metastasize, possibly preparing the LN for their later arrival. Metastatic, VEGF-A expressing SCC maintain their lymphangiogenic activity after metastasis to SLN

Figure 8: VEGF-A (vascular endothelial growth factor-A) expressing cancer cells induce tumor and lymph node (LN) lymphangiogenesis. In normal skin, lymphatic vessels are present in the dermis and maintain tissue fluid homeostasis. There is no detectable lymphangiogenesis within draining LN. squamous cell carcinoma (SCC) of K14/VEGF-A-transgenic mice induce primary, tumor-associated, lymphatic vessel growth but also lymphangiogenesis within sentinel lymph node (SLN), even before they metastasize, possibly preparing the LN for their later arrival. Metastatic, VEGF-A expressing SCC maintain their lymphangiogenic activity after metastasis to SLN