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Figure 3: (a) Photomicrograph showing hallmark cells with indented or embryoid appearing nuclei and abundant cytoplasm, (H and E, ×400); (b) Tumor cells showing nuclear and cytoplasmic anaplastic lymphoma kinase (ALK) expression; (c) membranous and Golgi pattern cluster of differentiation (CD) 30 expression (d) membranous CD45 and (e) membranous CD3 expression and negative expression for (f) CD56; (g) Pan cytokeratin (PANCK) and (h) epithelial membrane antigen (EMA) (×400), (i) (inset) Fluorescence in situ hybridisation (FISH) on tissue section with translocation affecting the 2p23locus as indicated by one red/green (non-rearranged) signal and one red signal and one separate green signal indicating the translocation

Figure 3: (a) Photomicrograph showing hallmark cells with indented or embryoid appearing nuclei and abundant cytoplasm, (H and E, ×400); (b) Tumor cells showing nuclear and cytoplasmic anaplastic lymphoma kinase (ALK) expression; (c) membranous and Golgi pattern cluster of differentiation (CD) 30 expression (d) membranous CD45 and (e) membranous CD3 expression and negative expression for (f) CD56; (g) Pan cytokeratin (PANCK) and (h) epithelial membrane antigen (EMA) (×400), (i) (inset) Fluorescence in situ hybridisation (FISH) on tissue section with translocation affecting the 2p23locus as indicated by one red/green (non-rearranged) signal and one red signal and one separate green signal indicating the translocation